Transcranial Direct Current Stimulation for Impulsivity and Food-related Impulsivity in Obesity
NCT ID: NCT04218383
Last Updated: 2021-01-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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SUSPENDED
NA
30 participants
INTERVENTIONAL
2020-02-03
2022-11-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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Experimental: Active Left OFC Group
2mA will be applied for 20 minutes with the tDCS anode applied to the left OFC and Cathode applied to the right primary motor cortex.
Transcranial Direct Current Stimulation
Anode placed over the OFC and cathode placed over the right primary motor cortex.
Sham Comparator: Sham left OFC Group
Current will be ramped up for 30s followed by a 30s ramp down to mimic the physical sensation of stimulation and habituation. The anode placed over the left OFC and cathode placed over the right primary motor cortex.
Transcranial Direct Current Stimulation
Anode placed over the OFC and cathode placed over the right primary motor cortex.
Interventions
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Transcranial Direct Current Stimulation
Anode placed over the OFC and cathode placed over the right primary motor cortex.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* have body mass index of 35 or above
* have had no recent change in medications in the 2 weeks prior participating in the study
* able to fast for 4 hours prior participating in the study
Exclusion Criteria
* Active Suicidal ideation
* Psychoactive Medication
* Past or current Gambling disorder
* Past or current Anorexia
* Past or current Bulimia Nervosa
* Past or current Psychosis
* Visual impairments preventing performance of the neuropsychological tasks
* Epilepsy
* Traumatic Brain Injury
* Stroke
* Neurological disorder affecting motor functions (Parkinsons, Huntington's, etc)
* Previous participation in tDCS research/treatment
18 Years
65 Years
ALL
Yes
Sponsors
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University of Calgary
OTHER
Responsible Party
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Principal Investigators
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Alexander McGirr, MD, MSc
Role: PRINCIPAL_INVESTIGATOR
University of Calgary
Locations
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University of Calgary
Calgary, Alberta, Canada
Countries
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References
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Kringelbach ML. The human orbitofrontal cortex: linking reward to hedonic experience. Nat Rev Neurosci. 2005 Sep;6(9):691-702. doi: 10.1038/nrn1747.
Mason AE, Vainik U, Acree M, Tomiyama AJ, Dagher A, Epel ES, Hecht FM. Improving Assessment of the Spectrum of Reward-Related Eating: The RED-13. Front Psychol. 2017 May 30;8:795. doi: 10.3389/fpsyg.2017.00795. eCollection 2017.
Finlayson G, King N, Blundell J. The role of implicit wanting in relation to explicit liking and wanting for food: implications for appetite control. Appetite. 2008 Jan;50(1):120-7. doi: 10.1016/j.appet.2007.06.007. Epub 2007 Jun 28.
Nijs IM, Franken IH, Muris P. The modified Trait and State Food-Cravings Questionnaires: development and validation of a general index of food craving. Appetite. 2007 Jul;49(1):38-46. doi: 10.1016/j.appet.2006.11.001. Epub 2006 Dec 21.
O'Doherty JP, Deichmann R, Critchley HD, Dolan RJ. Neural responses during anticipation of a primary taste reward. Neuron. 2002 Feb 28;33(5):815-26. doi: 10.1016/s0896-6273(02)00603-7.
Ouellet J, McGirr A, Van den Eynde F, Jollant F, Lepage M, Berlim MT. Enhancing decision-making and cognitive impulse control with transcranial direct current stimulation (tDCS) applied over the orbitofrontal cortex (OFC): A randomized and sham-controlled exploratory study. J Psychiatr Res. 2015 Oct;69:27-34. doi: 10.1016/j.jpsychires.2015.07.018. Epub 2015 Jul 17.
Phelan S, Hassenstab J, McCaffery JM, Sweet L, Raynor HA, Cohen RA, Wing RR. Cognitive interference from food cues in weight loss maintainers, normal weight, and obese individuals. Obesity (Silver Spring). 2011 Jan;19(1):69-73. doi: 10.1038/oby.2010.138. Epub 2010 Jun 10.
Pursey KM, Stanwell P, Callister RJ, Brain K, Collins CE, Burrows TL. Neural responses to visual food cues according to weight status: a systematic review of functional magnetic resonance imaging studies. Front Nutr. 2014 Jul 9;1:7. doi: 10.3389/fnut.2014.00007. eCollection 2014.
Ray MK, Sylvester MD, Osborn L, Helms J, Turan B, Burgess EE, Boggiano MM. The critical role of cognitive-based trait differences in transcranial direct current stimulation (tDCS) suppression of food craving and eating in frank obesity. Appetite. 2017 Sep 1;116:568-574. doi: 10.1016/j.appet.2017.05.046. Epub 2017 May 29.
Rothemund Y, Preuschhof C, Bohner G, Bauknecht HC, Klingebiel R, Flor H, Klapp BF. Differential activation of the dorsal striatum by high-calorie visual food stimuli in obese individuals. Neuroimage. 2007 Aug 15;37(2):410-21. doi: 10.1016/j.neuroimage.2007.05.008. Epub 2007 May 18.
Rush AJ, Trivedi MH, Ibrahim HM, Carmody TJ, Arnow B, Klein DN, Markowitz JC, Ninan PT, Kornstein S, Manber R, Thase ME, Kocsis JH, Keller MB. The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression. Biol Psychiatry. 2003 Sep 1;54(5):573-83. doi: 10.1016/s0006-3223(02)01866-8.
Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57.
Swinburn B, Sacks G, Ravussin E. Increased food energy supply is more than sufficient to explain the US epidemic of obesity. Am J Clin Nutr. 2009 Dec;90(6):1453-6. doi: 10.3945/ajcn.2009.28595. Epub 2009 Oct 14.
van der Laan LN, de Ridder DT, Viergever MA, Smeets PA. The first taste is always with the eyes: a meta-analysis on the neural correlates of processing visual food cues. Neuroimage. 2011 Mar 1;55(1):296-303. doi: 10.1016/j.neuroimage.2010.11.055. Epub 2010 Nov 25.
Other Identifiers
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REB19-0171
Identifier Type: -
Identifier Source: org_study_id
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