Supporting Decisions With Transcranial Direct Current Stimulation in Healthy Young and Elderly Individuals

NCT ID: NCT03959462

Last Updated: 2023-05-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

254 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-03-06

Study Completion Date

2022-12-30

Brief Summary

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Decisions are part of the daily life. On the neuronal level, activity in the dorsolateral prefrontal cortex (dlPFC) is important during complex decisions (e.g., whether something is emotional for a person or not). We apply transcranial direct current stimulation (tDCS) with the aim to increase dlPFC activity and thereby modulate decisions towards emotional content.

Detailed Description

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Conditions

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Real tDCS Sham tDCS

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Participants are allocated to one of 2 groups: real tDCS or sham.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators
Double blind design

Study Groups

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Real tDCS

20 min of 1 mA real anodal transcranial direct current stimulation applied via 5x7 cm rubber electrodes over the DLPFC (current density: 0.028 mA/cm2). Additional ramp-up and ramp-down phase at beginning and end of stimulation lasting for 15 s. Electrodes remain attached to the participant's head for the duration of the decision task.

Group Type EXPERIMENTAL

real anodal transcranial direct current stimulation

Intervention Type DEVICE

A neuroConn DC-Stimulator PLUS (neuroCare Group, Ilmenau, Germany) will be used.

Sham tDCS

30 s of 1 mA anodal tDCS applied via 5x7 cm rubber electrodes over the DLPFC (current density: 0.028 mA/cm2). Additional ramp-up and ramp-down phase at beginning and end of stimulation lasting for 15 s. Electrodes remain attached to the participant's head for the duration of the decision task.

Group Type SHAM_COMPARATOR

sham transcranial direct current stimulation

Intervention Type DEVICE

A neuroConn DC-Stimulator PLUS (neuroCare Group, Ilmenau, Germany) will be used.

Interventions

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real anodal transcranial direct current stimulation

A neuroConn DC-Stimulator PLUS (neuroCare Group, Ilmenau, Germany) will be used.

Intervention Type DEVICE

sham transcranial direct current stimulation

A neuroConn DC-Stimulator PLUS (neuroCare Group, Ilmenau, Germany) will be used.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Written informed consent
* Non-smokers
* Right-handedness
* Native German speakers or comparable level of fluency
* Normal or corrected-to-normal vision

Exclusion Criteria

* Neurological or psychiatric condition (other than diagnosed cognitive impairment)
* Past head injuries
* Magnetizable implants
* History of seizures
* Current or life-time alcohol or drug abuse
* Skin diseases
* tES in the 3 months preceding or during the present study
* Caffeine 3 hours prior to training
Minimum Eligible Age

20 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Novartis

INDUSTRY

Sponsor Role collaborator

University of Bern

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jessica Peter, PD

Role: PRINCIPAL_INVESTIGATOR

Universitäre psychiatrische Dienste Bern (UPD), University of Bern

Locations

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Klinik für Alterspsychiatrie und Psychotherapie UPD Bern

Bern, , Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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17C195

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

2017-01664

Identifier Type: -

Identifier Source: org_study_id

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