Interference With Cognitive Control by Transcranial Direct Current Stimulation

NCT ID: NCT01903538

Last Updated: 2013-07-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-07-31

Study Completion Date

2012-07-31

Brief Summary

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Insufficient cognitive control over emotional distracters is characteristic for major depressive disorder (MDD). Hypoactivation of the dorsolateral prefrontal cortex (dlPFC) is associated with this deficit. In this study the investigators assess the effect of a decrease of dlPFC activity in healthy subjects by cathodal transcranial direct current stimulation (tDCS) on cognitive control.

In a double-blinded, balanced randomized, sham-controlled crossover trial the investigators determine the effect of a single-session of cathodal tDCS to the left dlPFC on cognitive control in healthy subjects. To assess the cognitive control the investigators use a delayed response working memory task (DWM)and an arithmetic inhibition task (AIT) with pictures of varying valence.

Detailed Description

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Conditions

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Depression

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Cathodal transcranial direct current stimulation

Group Type EXPERIMENTAL

Cathodal transcranial direct current stimulation (tDCS)

Intervention Type DEVICE

Cathodal transcranial direct current stimulation (tDCS) 20min, 1mA, F3 (EEG 10/20), reference right M. deltoideus

Sham transcranial direct current stimulation

Group Type SHAM_COMPARATOR

Sham transcranial direct current stimulation

Intervention Type DEVICE

Sham transcranial direct current stimulation (tDCS) 40s, 1mA, F3 (EEG 10/20), reference right M. deltoideus

Interventions

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Cathodal transcranial direct current stimulation (tDCS)

Cathodal transcranial direct current stimulation (tDCS) 20min, 1mA, F3 (EEG 10/20), reference right M. deltoideus

Intervention Type DEVICE

Sham transcranial direct current stimulation

Sham transcranial direct current stimulation (tDCS) 40s, 1mA, F3 (EEG 10/20), reference right M. deltoideus

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

informed consent

Exclusion Criteria

psychiatric or neurological disorders seizures cardiac pacemakers
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital Tuebingen

OTHER

Sponsor Role lead

Responsible Party

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Christian Plewnia, MD

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Psychiatry and Psychotherapy, University of Tübingen

Tübingen, , Germany

Site Status

Countries

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Germany

Other Identifiers

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211/2010BO1_2

Identifier Type: -

Identifier Source: org_study_id

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