Cognitive Control of Negative Stimuli in BPD

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-01-31

Study Completion Date

2017-06-30

Brief Summary

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Borderline personality disorder (BPD) is characterized by impairments in the cognitive control of negative information. These impairments in cognitive control are presumably due to blunted activity of the dorsolateral prefrontal cortex (dlPFC) along with enhanced activations of the limbic system. However, the impact of an excitatory stimulation of the dlPFC still needs to be elucidated. In the present study, we therefore assigned 50 patients with BPD and 50 healthy controls to receive either anodal or sham stimulation of the right dlPFC in a double-blind, randomized, between-subjects design.

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Detailed Description

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Conditions

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Borderline Personality Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Anodal stimulation

transcranial DC stimulation : anodal

Group Type EXPERIMENTAL

transcranial DC stimulation : anodal

Intervention Type DEVICE

anodal stimulation of the right dlPFC (i.e. F4) for 20 minutes

Sham stimulation

transcranial DC stimulation : sham

Group Type SHAM_COMPARATOR

transcranial DC stimulation : sham

Intervention Type DEVICE

sham stimulation of the right dlPFC (i.e. F4) for 20 minutes

Interventions

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transcranial DC stimulation : anodal

anodal stimulation of the right dlPFC (i.e. F4) for 20 minutes

Intervention Type DEVICE

transcranial DC stimulation : sham

sham stimulation of the right dlPFC (i.e. F4) for 20 minutes

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of borderline personality disorder

* No current or previous diagnosis of a mental disorder

Exclusion Criteria

* Diagnosis of current or previous bipolar disorder
* Diagnosis of current substance dependency
* Diagnosis of current major depression
* Diagnosis of current or previous neurological disorders (e.g., epilepsy)
* Tattoos or scarred skin on the left shoulder or scalp (i.e. F4)

* More than 2 criteria of borderline personality disorder are met
* Diagnosis of current or previous neurological disorders (e.g., epilepsy)
* Intake of psychotropic medication
* Tattoos or scarred skin on the left shoulder or scalp (i.e. F4)

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes