Effects of Brain Stimulation During Nocturnal Sleep on Memory Consolidation in Elderly Healthy Subjects
NCT ID: NCT01791790
Last Updated: 2021-05-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
32 participants
INTERVENTIONAL
2013-01-31
2016-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
TRIPLE
Study Groups
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0,75 Hz stimulation
slow transcranial oscillating stimulation (\~0,75Hz) during periods of Slow Wave Sleep
Stimulation
SHAM stimulation
SHAM stimulation during periods of Slow Wave Sleep
SHAM
no stimulation
Interventions
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Stimulation
SHAM
no stimulation
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* unobtrusive, neuropsychological screening
* age: 50-90 years
* right handed
Exclusion Criteria
* epilepsy
* other severe neurological diseases eg., previous major stroke, brain tumour, dementia
* contraindications to MRI
50 Years
90 Years
ALL
Yes
Sponsors
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Charite University, Berlin, Germany
OTHER
Responsible Party
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Agnes Flöel
Prof. Agnes Flöel, MD
Principal Investigators
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Agnes Flöel, Professor
Role: STUDY_CHAIR
Charite Universitätsmedizin Berlin - Neurologie
Locations
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Charite CCM Neurologie Berlin
Berlin, , Germany
Countries
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References
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Marshall L, Helgadottir H, Molle M, Born J. Boosting slow oscillations during sleep potentiates memory. Nature. 2006 Nov 30;444(7119):610-3. doi: 10.1038/nature05278. Epub 2006 Nov 5.
Diekelmann S, Born J. The memory function of sleep. Nat Rev Neurosci. 2010 Feb;11(2):114-26. doi: 10.1038/nrn2762. Epub 2010 Jan 4.
Naismith SL, Lewis SJ, Rogers NL. Sleep-wake changes and cognition in neurodegenerative disease. Prog Brain Res. 2011;190:21-52. doi: 10.1016/B978-0-444-53817-8.00002-5.
Marshall L, Molle M, Hallschmid M, Born J. Transcranial direct current stimulation during sleep improves declarative memory. J Neurosci. 2004 Nov 3;24(44):9985-92. doi: 10.1523/JNEUROSCI.2725-04.2004.
Passmann S, Kulzow N, Ladenbauer J, Antonenko D, Grittner U, Tamm S, Floel A. Boosting Slow Oscillatory Activity Using tDCS during Early Nocturnal Slow Wave Sleep Does Not Improve Memory Consolidation in Healthy Older Adults. Brain Stimul. 2016 Sep-Oct;9(5):730-739. doi: 10.1016/j.brs.2016.04.016. Epub 2016 Apr 28.
Other Identifiers
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Nighttime sleep-tSOS-Old
Identifier Type: -
Identifier Source: org_study_id
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