Quantitative Myocardial Perfusion Reserve by Cardiovascular Magnetic Resonance

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

66 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-03-31

Study Completion Date

2023-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to validate a full-automated post-processing software for quantitative perfusion of the myocardium with magnetic resonance imaging.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Myocardial Blood Volume Measurement by Real-Time Myocardial Perfusion Echocardiography Correlates to Myocardial Compressibility by Cardiac Magnetic Resonance Imaging in Healthy Subjects

NCT04724304

Healthy Adults

COMPLETED NA

Normal Reference Values for 3T Cardiac Parametric Mapping

NCT06784427

Cardiac Imaging Cardiac Imaging Techniques

COMPLETED

Improved Prediction of Functional Recovery After Revascularisation Using Combined Assessment of Myocardial Ischaemia and Viability by CMR - Pilot Study

NCT03798652

Cardiovascular Diseases Ischemic Cardiomyopathy Cardiac Ischemia

UNKNOWN

Study of Blood Flow in Heart Muscle

NCT00001631

Coronary Disease Healthy Hypertrophic Cardiomyopathy +1 more

COMPLETED PHASE2

Edema and Fibrosis CMR Imaging in Cardiomyopathy

NCT03534726

Cardiomyopathies

ACTIVE_NOT_RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Cardiac magnetic resonance (CMR) imaging is a wide available technique for the diagnosis of myocardial ischemia. However, myocardial first-pass perfusion evaluation has been limited due to the moderate accuracy of the currently available qualitative and semiquantitative methods used to assess myocardial perfusion, and due to the lack of efficient absolute quantitative methods. Some CMR techniques and post-processing mathematical models have been developed for quantitative measurement of myocardial blood flow reserve with perfusion CMR under pharmacological stress. Measurement of these parameters with CMR have been shown to increase the accuracy of CMR in diagnosing myocardial ischemia, but most of these methods present technical challenges and have unreasonably time consuming post-processing. The aim of this study is to validate a full automated post-processing software for first pass perfusion CMR images that results in automated generated quantitative perfusion color maps.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Myocardial Ischemia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Healthy volunteers

Healthy subjects with normal 12-lead electrocardiogram at rest.

myocardial perfusion with magnetic resonance imaging

Intervention Type OTHER

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

myocardial perfusion with magnetic resonance imaging

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* healthy individuals with normal 12-lead electrocardiogram at rest.

Exclusion Criteria

* systolic blood pressure below 90 mmHg;
* bradycardia (\< 45 heart beats/minute);
* intake of caffeine or caffeine-containing drink/medicine 24 hours prior to the examination;
* impaired renal function assessed by venous blood sample.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes