CMR Assessment of Cardiac Microvascular Dysfunction in Patients With HFpEF
NCT ID: NCT06316661
Last Updated: 2024-03-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
60 participants
OBSERVATIONAL
2019-03-01
2024-12-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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HFpEF
patients with HFpEF
stress perfusion cardiac magnetic resonance
stress perfusion cardiac magnetic resonance according to guidelines, with quantitative evaluation for microvascular dysfunction assessment
cardiopulmonary exercise test
bike exercise with ECG and non invasive respiratory gas exchange monitoring
healthy volunteers
healthy volunteers matched for age and sex
stress perfusion cardiac magnetic resonance
stress perfusion cardiac magnetic resonance according to guidelines, with quantitative evaluation for microvascular dysfunction assessment
cardiopulmonary exercise test
bike exercise with ECG and non invasive respiratory gas exchange monitoring
Interventions
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stress perfusion cardiac magnetic resonance
stress perfusion cardiac magnetic resonance according to guidelines, with quantitative evaluation for microvascular dysfunction assessment
cardiopulmonary exercise test
bike exercise with ECG and non invasive respiratory gas exchange monitoring
Eligibility Criteria
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Inclusion Criteria
* Able to provide written informed consent
* Diagnosis of HFpEF as defined by the 2016 ESC Guidelines (only for HFpEF group)
Exclusion Criteria
* Absolute contraindication to adenosine perfusion cardiac MRI (including uncontrolled asthma and severe chronic kidney failure, defined as glomerular filtration rate \< 30ml(min/kg)
* Atrial fibrillation
* Previous chemotherapy and/or mediastinal radiotherapy
* Known CAD
* Diabetes Mellitus
* Systemic inflammatory diseases
* Any other medical condition which, in the Investigators' opinion, could affect the study results
* Only for control group: any known cardiac, pulmonary, haematological or neoplastic known medical condition and/or any chronic therapy.
18 Years
ALL
Yes
Sponsors
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Istituto Auxologico Italiano
OTHER
Responsible Party
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Locations
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IRCCS Istituto Auxologico Italiano
Milan, , Italy
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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09C921
Identifier Type: -
Identifier Source: org_study_id
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