Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
100 participants
INTERVENTIONAL
2017-02-20
2024-06-20
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Healthy volunteers
Sedentary healthy subjects will be recruited in this study. MRI, skin auto-fluorescence measures and blood sampling will be performed
Blood sampling
Blood sampling will be performed at inclusion to investigate some biological eligibility criteria, and the day of MRI in order to analyse fibrosis biomarkers and collagen synthesis biomarkers
MRI
MRI will be performed to measure interstitial fibrosis
Skin auto-fluorescence
Skin auto-fluorescence measures will be performed to measure advanced glycation end-products (AGE) produced by collagen degradation
Interventions
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Blood sampling
Blood sampling will be performed at inclusion to investigate some biological eligibility criteria, and the day of MRI in order to analyse fibrosis biomarkers and collagen synthesis biomarkers
MRI
MRI will be performed to measure interstitial fibrosis
Skin auto-fluorescence
Skin auto-fluorescence measures will be performed to measure advanced glycation end-products (AGE) produced by collagen degradation
Eligibility Criteria
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Inclusion Criteria
* no history of smoking, diabetes, myocardial infarction, heart failure, hypertension (\<140 or \<90 mmHg) and no anti-hypertensive or cardiovascular-related medications
* no familial history of early myocardial ischemia
* body mass index (BMI) \<30kg/m2
* normal routine lipid blood analysis
* glycemia \<1.26g/l
* normal electrocardiogram (ECG)
Exclusion Criteria
* hepatic insufficiency
* pregnancy
* claustrophobia
* MRI contrast allergy,
* general contraindications to MRI such as pacemaker, etc.
18 Years
ALL
Yes
Sponsors
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Hospices Civils de Lyon
OTHER
Responsible Party
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Principal Investigators
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Pierre CROISILLE, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
CHU SAINT-ETIENNE
Locations
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Département de Radiologie, CHU Saint-Etienne - Hôpital Nord
Saint-Etienne, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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69HCL15_0744
Identifier Type: -
Identifier Source: org_study_id
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