Cardiac Magnetic Resonance Assessment for Heart Failure With Preserved Ejection Fraction
NCT ID: NCT04063579
Last Updated: 2023-05-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
172 participants
INTERVENTIONAL
2018-06-01
2021-12-31
Brief Summary
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Detailed Description
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It is therefore proposed to investigate HFpEF using cardiovascular magnetic resonance imaging (CMR), as an alternative non-invasive diagnostic tool which carries lower risk than invasive procedures.
The study aims to: (1) access the utility of CMR-FT as a new indicator to diagnose diastolic dysfunction by differentiating HFpEF patients from non-HFpEF patient and normal volunteers. (2) Compare accuracy of CMR-FT to CMR tagging and phase contrast imaging.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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Patients with heart failure with preserved ejection fraction
Cardiac Magnetic Resonance, Echocardiogram, Blood investigation (NT-proBNP), cardiac catheterization
Imaging, blood tests, LV pressure measurement
Non-heart failure patients
Cardiac Magnetic Resonance, Echocardiogram, Blood investigation (NT-proBNP), cardiac catheterization
Imaging, blood tests, LV pressure measurement
Normal Volunteers
Cardiac Magnetic Resonance, Echocardiogram, Blood investigation (NT-proBNP)
Imaging and Blood tests
Interventions
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Cardiac Magnetic Resonance, Echocardiogram, Blood investigation (NT-proBNP), cardiac catheterization
Imaging, blood tests, LV pressure measurement
Cardiac Magnetic Resonance, Echocardiogram, Blood investigation (NT-proBNP)
Imaging and Blood tests
Eligibility Criteria
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Inclusion Criteria
* Patients undergoing coronary catheterisation for stable chest pain with no evidence of diastolic dysfunction, heart failure, infarct, left ventricular ejection fraction \<50% or significant coronary artery disease (ie. \>50% narrowing of one or more coronary arteries)
* Volunteers must be asymptomatic with no cardiac risk factors and no previous cardiac history
Exclusion Criteria
* Significant underlying ischaemia based on clinical history and non-invasive imaging or catheter coronary angiography if indicated.
* Contraindication to CMR study
* Estimated glomerular filtration rate \<30 ml/min/1.73 m2
* More than moderate valvular disease
* Severe pulmonary disease (ie. FEV1 \<- 50% predicted)
* Cardiomyopathy
* Constrictive pericarditis
ALL
Yes
Sponsors
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The University of Hong Kong
OTHER
Responsible Party
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Locations
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The University of Hong Kong
Hong Kong, , Hong Kong
Countries
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References
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Ng MY, Kwan CT, Yap PM, Fung SY, Tang HS, Tse WWV, Kwan CNF, Chow YHP, Yiu NC, Lee YP, Fong AHT, Hwang S, Fong ZFW, Ren QW, Wu MZ, Wan EYF, Lee KCK, Leung CY, Li A, Montero D, Vardhanabhuti V, Hai J, Siu CW, Tse HF, Pennell DJ, Mohiaddin R, Senior R, Yiu KH. Diagnostic accuracy of cardiovascular magnetic resonance strain analysis and atrial size to identify heart failure with preserved ejection fraction. Eur Heart J Open. 2023 Mar 7;3(2):oead021. doi: 10.1093/ehjopen/oead021. eCollection 2023 Mar.
Other Identifiers
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UW18-022
Identifier Type: -
Identifier Source: org_study_id
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