Cardiac Magnetic Resonance Tomography for Heart Failure With Preserved Ejection Fraction

NCT ID: NCT05322109

Last Updated: 2022-04-11

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 190 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-04-23
• Study Completion Date: 2021-12-12

Brief Summary

The diagnosis of heart failure with preserved ejection fraction has so far been made primarily according to criteria determined by echocardiography, or invasively by measuring the left ventricular filling pressures. Increasingly, CMR is also evaluated with regard to the diagnosis of cardiac insufficiency with preserved pump function.However, it is still unclear which parameters can be used meaningfully for diagnostics.To answer this question, the investigators want to retrospectively evaluate data collected from patients with a clinical indication for CMR and coronary angiography.

Detailed Description

Heart failure with preserved pump function is a common disease that is associated with a high level of suffering for the patient. The diagnosis has so far been made primarily according to criteria determined by echocardiography, or invasively by measuring the left ventricular filling pressures.

With its high spatial resolution and the possibility of tissue-specific diagnostics, cardiac MRI (CMR) offers outstanding possibilities in cardiac imaging without exposing the patient to ionizing radiation. Increasingly, CMR is also evaluated with regard to the diagnosis of cardiac insufficiency with preserved pump function. However, it is still unclear which parameters can be used meaningfully for diagnostics. There is evidence for a correlation with invasively increased LVEDP, although the number of patients examined in the previous studies was still small. In addition, possible influences from medication and clinical parameters were not examined.

To answer this question, the investigators want to retrospectively evaluate data collected from patients with a clinical indication. The significance of the study is that in the future CMR could supplement echocardiography in the diagnosis of HFpEF and further reduce the need for invasive diagnostics.

Conditions

Heart Failure, Diastolic

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Interventions

CMR

Clinically indicated cardiac magnetic resonance tomography executed according to international guideline recommendations.

Intervention Type: DIAGNOSTIC_TEST

Other Intervention Names

Cardiac magnetic resonance tomography

Eligibility Criteria

Inclusion Criteria

• Patients with CMR and left heart catheterization including LVEDP measurement within the same month

Exclusion Criteria

• Severe Valve Dysfunction or Pericardial/Pleural Disease
• Contraindictaion for CR or Cath

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

German Heart Institute

OTHER

Sponsor Role: lead

Responsible Party

Sebastian Kelle

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Deutsches Herzzentrum Berlin

Berlin, , Germany

Countries

Germany

Other Identifiers

EA2/017/22

Identifier Type: -

Identifier Source: org_study_id