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Strain-Encoded Magnetic Resonance Imaging in Acute Myocardial Infarction

NCT ID: NCT00752713

Last Updated: 2008-09-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

48 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-01-31

Study Completion Date

2008-01-31

Brief Summary

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The aim of the study was therefore to evaluate whether myocardial deformation imaging performed by SENC allows for quantification of regional left ventricular function and is related to transmurality states of infarcted tissue in patients with acute myocardial infarction (AMI).

Detailed Description

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CMR was performed in 38 consecutive patients with AMI 3±1 days after successful reperfusion using a clinical 1.5 Tesla MR-scanner. Ten healthy volunteers served as controls. SENC is a technique that directly measures peak circumferential strain from long-axis views and peak longitudinal strain from short axis views. Measurements were obtained for each segment in a modified 17 segment model. Wall motion and infarcted tissue were evaluated semi-quantitatively from SSFP cine sequences and contrast-enhanced-MR-images and were then related to myocardial strain. Comparison of peak circumferential strain assessed by SENC and MR-tagging was performed.

Conditions

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Acute Myocardial Infarction

Keywords

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AMI, Reperfusion successful

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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1

Patients presenting to hospital with AMI

cardiac MRI

Intervention Type PROCEDURE

cardiac MRI at one time point for group 1 after intervention for group 2 at any time point

2

healthy volunteers as control group

cardiac MRI

Intervention Type PROCEDURE

cardiac MRI at one time point for group 1 after intervention for group 2 at any time point

Interventions

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cardiac MRI

cardiac MRI at one time point for group 1 after intervention for group 2 at any time point

Intervention Type PROCEDURE

Other Intervention Names

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cardiac resonance magnetic imaging

Eligibility Criteria

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Inclusion Criteria

* Patients with AMI after successful reperfusion
* Healthy volunteers in control group

Exclusion Criteria

* No reperfusion
Minimum Eligible Age

30 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Heidelberg University

OTHER

Sponsor Role collaborator

RWTH Aachen University

OTHER

Sponsor Role lead

Responsible Party

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Medical Clinic III, University Hospital Heidelberg

Principal Investigators

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Mirja Neizel, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital Heidelberg

Locations

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University Hospital Heidelberg

Heidelberg, , Germany

Site Status

Countries

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Germany

References

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Neizel M, Korosoglou G, Lossnitzer D, Kuhl H, Hoffmann R, Ocklenburg C, Giannitsis E, Osman NF, Katus HA, Steen H. Impact of systolic and diastolic deformation indexes assessed by strain-encoded imaging to predict persistent severe myocardial dysfunction in patients after acute myocardial infarction at follow-up. J Am Coll Cardiol. 2010 Sep 21;56(13):1056-62. doi: 10.1016/j.jacc.2010.02.070.

Reference Type DERIVED
PMID: 20846606 (View on PubMed)

Other Identifiers

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SENC in AMI

Identifier Type: -

Identifier Source: org_study_id