CCTA-based Coronary Plaque Characterization and High-sensitive Troponin T for the Prediction of Cardiovascular Outcomes

NCT ID: NCT02030704

Last Updated: 2018-09-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-02-29

Study Completion Date

2018-09-30

Brief Summary

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To determine the ability of semi-automated plaque assessment in cardiac computed tomography angiography (CCTA) and high sensitive troponin T (hsTnT) for the risk stratification of patients at intermediate risk for coronary artery disease (CAD).

Detailed Description

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Conditions

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Coronary Artery Disease Noninvasive Plaque Characterization

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Atherosclerotic Plaque

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Clinical indication for CCTA according to the current appropriate use criteria

Exclusion Criteria

* non-sinus rhythm
* acute coronary syndromes
* cardiomyopathies
* moderate or severe valvular disease
* elevated serum creatinine (\>1.5 mg/dl)
* history or ECG signs of previous myocardial infarction
* severe iodine allergy.
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Semmelweis University Heart and Vascular Center

OTHER

Sponsor Role collaborator

Heidelberg University

OTHER

Sponsor Role collaborator

University Hospital Heidelberg

OTHER

Sponsor Role lead

Responsible Party

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GKorosoglou

Prof. Dr. med.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Grigorios Korosoglou, Prof. Dr. med.

Role: PRINCIPAL_INVESTIGATOR

University of Heidelberg, Department of Cardiology, Heidelberg, Germany.

Locations

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University of Heidelberg, Department of Cardiology

Heidelberg, Baden-Wurttemberg, Germany

Site Status

MTA-SE Lendület Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University

Budapest, , Hungary

Site Status

Countries

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Germany Hungary

References

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Korosoglou G, Mueller D, Lehrke S, Steen H, Hosch W, Heye T, Kauczor HU, Giannitsis E, Katus HA. Quantitative assessment of stenosis severity and atherosclerotic plaque composition using 256-slice computed tomography. Eur Radiol. 2010 Aug;20(8):1841-50. doi: 10.1007/s00330-010-1753-3. Epub 2010 Mar 20.

Reference Type BACKGROUND
PMID: 20306078 (View on PubMed)

Other Identifiers

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HDCCTA01

Identifier Type: -

Identifier Source: org_study_id

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