Predicting the Risk of Non-culprit Coronary Artery Disease After a Heart Attack

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-04-25

Study Completion Date

2028-04-30

Brief Summary

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Heart attacks caused by the complete blockage of a heart artery are treated by opening it with a stent. However, most people will also have 'non-culprit' narrowings found in their other arteries at this time.

Although in general people do better if these non-culprit narrowings are also treated with stents if they look severe, this process has problems. This is because narrowings that look severe may be stable and not cause any trouble. For these people a stent is a wasted procedure and unnecessary risk. On the other hand, narrowings that are currently left alone because they appear mild, may progress and cause a heart attack.

Participants who have had a heart attack will have a scan from inside the heart arteries during an angiogram (optical coherence tomography, OCT) and a magnetic resonance angiogram (MRA).

If the investigators can show that it is possible to accurately predict which non-culprit narrowings are going to progress and which are going to stabilise, medical professionals may be able to better target their treatments after a heart attack.

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Detailed Description

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Conditions

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Coronary Artery Disease ST Elevation Myocardial Infarction Ischemic Heart Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Standard of care

Patients after ST-elevation myocardial infarction with non-culprit coronary artery disease.

Optical coherence tomography and pressure wire assessment

Intervention Type DIAGNOSTIC_TEST

Non-culprit coronary arteries

Cardiac magnetic resonance angiogram

Intervention Type DIAGNOSTIC_TEST

1.5T

Interventions

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Optical coherence tomography and pressure wire assessment

Non-culprit coronary arteries

Intervention Type DIAGNOSTIC_TEST

Cardiac magnetic resonance angiogram

1.5T

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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OCT (Abbott) PressureWire X (Abbott) Cardiac MRI

Eligibility Criteria

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Inclusion Criteria

* Successful primary percutaneous coronary intervention (PCI) within the previous week with no major complications at the index procedure
* Bystander disease in a non-culprit vessel planned for clinically indicated staged angiography +/- PCI
* Able to provide written informed consent.

Exclusion Criteria

* Cardiogenic shock requiring intubation, inotropes or a mechanical support device
* Creatinine clearance \<30ml/min
* Prior coronary artery bypass grafting
* Life expectancy less than 3 years
* Pregnancy.
* Target lesion in the left main coronary artery
* Severe calcification or tortuosity that would threaten safe placement of a pressure wire or OCT catheter
* Chronic total occlusion of a major epicardial vessel.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No