CCTA Improves Clinical Management of Stable Chest Pain

NCT ID: NCT04691037

Last Updated: 2024-03-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

50000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-01

Study Completion Date

2030-01-01

Brief Summary

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The investigator aims to prospectively enroll patients who were referred for coronary computed tomography angiography (CCTA) for the assessment of stable chest pain (SCP) suspected of obstructive coronary artery disease (CAD). All patients underwent CCTA according to established guidelines and local institutional protocols. The imaging data were evaluated using different image post-processing software to comprehensively analyse anatomical, functional and histological information of coronary. This study will determine if CCTA-based imaging evaluation can provide more informaton to improve clinical management for SCP, including fewer MACE and better decision-making of downstream investigations and therapeutic interventions.

Detailed Description

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Conditions

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Coronary Computed Tomography Angiography Stable Chest Pain Optimal Medical Therapy Invasive Coronary Angiography Revascularization Major Adverse Cardiovascular Events Coronary Artery Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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CCTA

CCTA

Intervention Type DIAGNOSTIC_TEST

All patients underwent CCTA according to established guidelines and local institutional protocols. The imaging data were evaluated using different image post-processing software to comprehensively analyse anatomical, functional and histological information of coronary.

Interventions

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CCTA

All patients underwent CCTA according to established guidelines and local institutional protocols. The imaging data were evaluated using different image post-processing software to comprehensively analyse anatomical, functional and histological information of coronary.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* symptomatic patients with SCP suspected of obstructive CAD.
* referred for CCTA for the assessment of SCP.
* ≥18 years of age.
* signed informed consent.

Exclusion Criteria

* acute coronary syndromes
* previous CAD or coronary revascularization
* nonsinus rhythm
* cardiomyopathy, valvular disease, congenital heart disease or left cardiac insufficiency because of other reasons
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tianjin Chest Hospital

OTHER

Sponsor Role lead

Responsible Party

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Zhou Jia

Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Beijing Chaoyang Hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Hebei Petrochina Central Hospital

Langfang, Hebei, China

Site Status RECRUITING

Tianjin Chest Hospital

Tianjin, Tianjin Municipality, China

Site Status RECRUITING

Tianjin First Central Hospital

Tianjin, Tianjin Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Jia Zhou

Role: CONTACT

+8615522485560

Facility Contacts

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Yahang Tan

Role: primary

Tao Cheng

Role: primary

+8615303365846

Jia Zhou

Role: primary

+15522485560

Ting Xin

Role: primary

+8615102204614

References

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Tan Y, Liu C, Chen T, Li Y, Wang C, Zhao J, Zhou J. Coronary Artery Calcium Score-Weighted Clinical Likelihood Model Performance in Patients with Stable Chest Pain and Coronary Artery Calcium Scores of Zero. Rev Cardiovasc Med. 2024 Mar 4;25(3):85. doi: 10.31083/j.rcm2503085. eCollection 2024 Mar.

Reference Type DERIVED
PMID: 39076944 (View on PubMed)

Zhou J, Li C, Zhang H, Liu C, Yang J, Zhao J, Hou Y, Tan Y, Wang H, Li Y, Xie C, Wang M, Wang C, Zhang E, Wang S, Zhao P, Shan D, Liang S, Gao Y, Huo Y, Cong H, Guo Z, Chen Y. Association between Coronary Artery Disease Reporting and Data System-recommended Post-Coronary CT Angiography Management and Clinical Outcomes in Patients with Stable Chest Pain from a Chinese Registry. Radiology. 2023 Jun;307(5):e222965. doi: 10.1148/radiol.222965.

Reference Type DERIVED
PMID: 37310243 (View on PubMed)

Jiang H, Feng J, Feng C, Ren P, Ren K, Jin Y, Zhou J. Validation and Comparison of PROMISE and CONFIRM Model to Predict High-Risk Coronary Artery Disease in Symptomatic and Diabetes Mellitus Patients. Rev Cardiovasc Med. 2022 Mar 1;23(3):80. doi: 10.31083/j.rcm2303080.

Reference Type DERIVED
PMID: 35345247 (View on PubMed)

Other Identifiers

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2017-KY-004

Identifier Type: -

Identifier Source: org_study_id

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