Study of Motor Representations in Healthy Subjects and Amnestic MCI

NCT ID: NCT02574182

Last Updated: 2021-07-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

97 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-02-24

Study Completion Date

2017-05-13

Brief Summary

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Walking, Brain and Functional Magnetic Resonance Imaging Study of motor representations in healthy subjects and amnesic MCI.

Detailed Description

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Review and compare mapping brain activation in Magnetic Resonance Imaging about healthy subjects according to age (\<40 years and\> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination of the walk.

Conditions

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Mild Cognitive Impairment

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Control subjects under 40 years

Brain MRI Simulated walking with Corvit boots Records gait parameters on Gaitrite carpet

Brain MRI

Intervention Type RADIATION

Brain MRI (Magnetic Resonance Imaging) brain is a painless test that allows to visualize the different brain structures.

Korvit, device made up of 2 shoes which reproduces the feeling to go. The Korvit® system appears possible to analyze the activated cerebral zones and to thus try to better understand the operation of the brain during walk.

The GAITRite is a carpet for recording the walking operating parameters

Control subjects over 60 years

Brain MRI Simulated walking with Corvit boots Records gait parameters on Gaitrite carpet

Brain MRI

Intervention Type RADIATION

Brain MRI (Magnetic Resonance Imaging) brain is a painless test that allows to visualize the different brain structures.

Korvit, device made up of 2 shoes which reproduces the feeling to go. The Korvit® system appears possible to analyze the activated cerebral zones and to thus try to better understand the operation of the brain during walk.

The GAITRite is a carpet for recording the walking operating parameters

MCI subjects over 60 years

Brain MRI Simulated walking with Corvit boots Records gait parameters on Gaitrite carpet

Brain MRI

Intervention Type RADIATION

Brain MRI (Magnetic Resonance Imaging) brain is a painless test that allows to visualize the different brain structures.

Korvit, device made up of 2 shoes which reproduces the feeling to go. The Korvit® system appears possible to analyze the activated cerebral zones and to thus try to better understand the operation of the brain during walk.

The GAITRite is a carpet for recording the walking operating parameters

Interventions

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Brain MRI

Brain MRI (Magnetic Resonance Imaging) brain is a painless test that allows to visualize the different brain structures.

Korvit, device made up of 2 shoes which reproduces the feeling to go. The Korvit® system appears possible to analyze the activated cerebral zones and to thus try to better understand the operation of the brain during walk.

The GAITRite is a carpet for recording the walking operating parameters

Intervention Type RADIATION

Other Intervention Names

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KORVIT GAITRite

Eligibility Criteria

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Inclusion Criteria

* Obtaining the signature of consent to participation in the study
* Age above 18 years
* Lack dementia as NICDS-ADRDA criteria
* Lack of pre-existing musculoskeletal disorders, regardless of the cause (except MCI).
* Absence of a history of stroke or other cerebrovascular disease with spinal sensorimotor sequelae.
* No cons-indication for performing a brain MRI.
* Witennses, population of young (\<40 years)
* Witnesses ,population of older subjects (\> 60 years)
* Witnesses Lack of MCI
* MCI patients, criteria MCI criteria according to Dubois

Exclusion Criteria

* Refusal of MRI.
* Contraindications to brain MRI.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Angers

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Michael Dinomais, MD

Role: PRINCIPAL_INVESTIGATOR

UH Angers

Locations

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University Hospital Angers

Angers, Pays de la Loire Region, France

Site Status

Countries

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France

References

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Dinomais M, Minassian AT, Tuilier T, Delion M, Wilke M, N'Guyen S, Richard I, Aube C, Menei P. Functional MRI comparison of passive and active movement: possible inhibitory role of supplementary motor area. Neuroreport. 2009 Oct 7;20(15):1351-5. doi: 10.1097/WNR.0b013e328330cd43.

Reference Type BACKGROUND
PMID: 19734813 (View on PubMed)

Beauchet O, Allali G, Berrut G, Hommet C, Dubost V, Assal F. Gait analysis in demented subjects: Interests and perspectives. Neuropsychiatr Dis Treat. 2008 Feb;4(1):155-60. doi: 10.2147/ndt.s2070.

Reference Type BACKGROUND
PMID: 18728766 (View on PubMed)

Rimmer E, Wojciechowska M, Stave C, Sganga A, O'Connell B. Implications of the Facing Dementia Survey for the general population, patients and caregivers across Europe. Int J Clin Pract Suppl. 2005 Mar;(146):17-24. doi: 10.1111/j.1368-504x.2005.00482.x.

Reference Type BACKGROUND
PMID: 15801187 (View on PubMed)

Ogawa S, Lee TM, Nayak AS, Glynn P. Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med. 1990 Apr;14(1):68-78. doi: 10.1002/mrm.1910140108.

Reference Type BACKGROUND
PMID: 2161986 (View on PubMed)

Beauchet O, Allali G, Launay C, Herrmann FR, Annweiler C. Gait variability at fast-pace walking speed: a biomarker of mild cognitive impairment? J Nutr Health Aging. 2013 Mar;17(3):235-9. doi: 10.1007/s12603-012-0394-4.

Reference Type BACKGROUND
PMID: 23459976 (View on PubMed)

Other Identifiers

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CHU PROMOTEUR 2014/32

Identifier Type: -

Identifier Source: org_study_id

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