Magnetic Resonance Imaging Studies of Motor and Thought Processes

NCT ID: NCT00001361

Last Updated: 2008-03-04

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 610 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 1992-10-31
• Study Completion Date: 2002-01-31

Brief Summary

Magnetic resonance imaging (MRI) is a diagnostic tool that creates high quality images of the human body without the use of X-ray (radiation). MRI is especially useful when studying the brain, because it can provide information about certain brain functions. In addition, MRI is much better than standard X-rays at showing areas of the brain close to the skull and detecting changes in the brain associated with neurological diseases. In this study researchers will use MRI to gather information about the processes that control human movement and sensory processing.

The purpose of the study is to investigate how the brain is activated when remembering, thinking, or recognizing objects. Researchers would like to determine what happens to brain functions when patients have trouble remembering, thinking, or recognizing objects following the start of disorders in the brain and nervous system. In addition, this study will investigate the processes of motor control in healthy volunteers and patients with disease.

Detailed Description

The main purpose of the studies presented in this protocol is to investigate the physiology of motor control in health as well as the pathophysiological modifications taking place during disease. Patients and normal volunteers will be scanned at rest and during different tasks, either while making repetitive movements or undergoing sensory stimulation. These studies should provide new insight concerning the processes that control human movement and sensory processing. The studies described in this protocol will be conducted by systems operating on 1.5 Tesla up to 4 Tesla, including a system at 3 Tesla which is going to be installed in near future.

Conditions

Cerebrovascular Disorder; Healthy; Movement Disorder; Nervous System Disease; Spinal Cord Injury

Eligibility Criteria

Inclusion Criteria

Patients with movement disorder and normal volunteers.

• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

Sponsor Role: lead

Locations

National Institute of Neurological Disorders and Stroke (NINDS)

Bethesda, Maryland, United States

Countries

United States

References

Sadato N, Ibanez V, Campbell G, Deiber MP, Le Bihan D, Hallett M. Frequency-dependent changes of regional cerebral blood flow during finger movements: functional MRI compared to PET. J Cereb Blood Flow Metab. 1997 Jun;17(6):670-9. doi: 10.1097/00004647-199706000-00008.

Reference Type: BACKGROUND

PMID: 9236723 (View on PubMed)

Karni A, Meyer G, Jezzard P, Adams MM, Turner R, Ungerleider LG. Functional MRI evidence for adult motor cortex plasticity during motor skill learning. Nature. 1995 Sep 14;377(6545):155-8. doi: 10.1038/377155a0.

Reference Type: BACKGROUND

PMID: 7675082 (View on PubMed)

Aquilonius SM. What has PET told us about Parkinson's disease? Acta Neurol Scand Suppl. 1991;136:37-9. doi: 10.1111/j.1600-0404.1991.tb05018.x.

Reference Type: BACKGROUND

PMID: 1801535 (View on PubMed)

Other Identifiers

93-N-0010

Identifier Type: -

Identifier Source: secondary_id

930010

Identifier Type: -

Identifier Source: org_study_id