Functional Neuroimaging in Parkinson's Disease

NCT ID: NCT04904068

Last Updated: 2025-04-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-09-15

Study Completion Date

2025-11-02

Brief Summary

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The study uses magnetic resonance imaging (MRI) to better understand changes in the brain underlying motor symptoms affecting upper and lower limbs in Parkinson's disease.

Detailed Description

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There is a tremendous need to improve the understanding of the pathophysiology underlying motor symptoms in Parkinson's disease in order to optimize existing treatment options/develop new therapies. This study seeks to further the understanding of impaired movement in Parkinson's disease by examining brain changes and how these relate to changes in motor behavior.

The study uses magnetic resonance imaging (MRI), a noninvasive imaging technique that does not include X-rays. MRI will assess brain activity in response to simple and coordinated movements of the upper and lower limbs that participants have to perform inside the MRI scanner. Motor and cognitive function outside the scanner using various clinical and behavioral tests will also be assessed. The study includes 1 visit to the University of Delaware.

Conditions

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Parkinson Disease Healthy Aging

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Parkinson's disease

Individuals with a clinical diagnosis of Parkinson's disease.

No interventions assigned to this group

Healthy

Healthy individuals with no known neurological disorders.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* A clinical diagnosis of Parkinson's disease
* No neurological disorders if interested in participating as a control participant
* Must be capable of providing informed consent
* Must be eligible to receive a brain MRI

Exclusion Criteria

* A secondary movement disorder diagnosis in addition to Parkinson's disease
* Dementia
* Medical conditions that may make one ineligible for receiving a brain MRI
* Inability to provide informed consent
* Control/healthy group: neurological disorders
* Control/healthy group: cannot walk without an assistive device/mobility problems
Minimum Eligible Age

45 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Delaware

OTHER

Sponsor Role lead

Responsible Party

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Roxana Burciu

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Roxana G Burciu, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Delaware

Locations

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University of Delaware

Newark, Delaware, United States

Site Status

Countries

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United States

Other Identifiers

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1407867

Identifier Type: -

Identifier Source: org_study_id

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