Multi-modality MRI Study on Prediction for Mild Cognitive Impairment Conversion

NCT ID: NCT02353884

Last Updated: 2015-02-03

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 150 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-01-31
• Study Completion Date: 2012-12-31

Brief Summary

The purpose of this study is to find the characteristics of mild cognitive impairment (MCI) using technology of Multi-Modality MRI , including structural MRI, functional MRI and diffusion tensor imaging(DTI). Then analyze the difference between progressive MCI (MCIp) and stable MCI (MCIs) and further construct the predictable classifier from MCI to Alzheimer's disease (AD) based on Multi-Modality MRI characteristics of MCI patients.

Detailed Description

The cognition of MCI is between normal healthy and AD, which is thought the transitional stage of AD. Patients with MCI have heavy risk to convert to AD, so in this study, the investigators focus on the exploration of the characteristics of mild cognitive impairment (MCI) using technology of Multi-Modality MRI, including structural MRI, functional MRI and DTI. Then the investigators further study the patients who convert to AD and explore their MRI characteristics on baseline, in order to construct the predictable classifier from MCI to AD. The investigators want to achieve the early diagnosis of AD and help clinicians interfere with the progress of this disease.

Conditions

Mild Cognitive Impairment; Alzheimer's Disease

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

MCIp,MCIs

progressive MCI：those convert to AD in two years, stable MCI

No interventions assigned to this group

MCI，HC

mild cognitive impairment, healthy control

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Age is between 55 to 75 years old
• Memory loss complaint and confirmed by an informant
• Cognitive impairment in single or multiple domains, adjusted for age and education
• Normal or near-normal performance on general cognitive function and no or minimum impairment of daily life activities
• A Clinical Dementia Rating (CDR) score is 0.5 and consistent with the boundary of neuropsychological scale
• Failure to meet the criteria for dementia
• Must be able to accept examination of MRI, sight and hearing allow to complete test
• Right handedness

Exclusion Criteria

• Other diseases that cause cognitive impairment, such as thyroid disease, stroke and so on
• People who have severe visual and hearing impairment

• Minimum Eligible Age: 55 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Xuanwu Hospital, Beijing

OTHER

Sponsor Role: collaborator

XuanwuH 2

OTHER

Sponsor Role: lead

Responsible Party

XuanwuH 2

Chief physician

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

Department of Neurolgy,Xuanwu Hospital of Capital Medical University

Beijing, Beijing Municipality, China

Countries

China

References

Sheng C, Sun Y, Wang M, Wang X, Liu Y, Pang D, Liu J, Bi X, Du W, Zhao M, Li Y, Li X, Jiang J, Han Y. Combining Visual Rating Scales for Medial Temporal Lobe Atrophy and Posterior Atrophy to Identify Amnestic Mild Cognitive Impairment from Cognitively Normal Older Adults: Evidence Based on Two Cohorts. J Alzheimers Dis. 2020;77(1):323-337. doi: 10.3233/JAD-200016.

Reference Type: DERIVED

PMID: 32716355 (View on PubMed)

Yang L, Yan Y, Wang Y, Hu X, Lu J, Chan P, Yan T, Han Y. Gradual Disturbances of the Amplitude of Low-Frequency Fluctuations (ALFF) and Fractional ALFF in Alzheimer Spectrum. Front Neurosci. 2018 Dec 20;12:975. doi: 10.3389/fnins.2018.00975. eCollection 2018.

Reference Type: DERIVED

PMID: 30618593 (View on PubMed)

Other Identifiers

hanying3

Identifier Type: -

Identifier Source: org_study_id