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Evaluation of Alteration by Magnetic Resonance Imaging (MRI) in Dementia Among Elderly Subjects

NCT ID: NCT00951197

Last Updated: 2012-04-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

318 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-04-30

Study Completion Date

2011-03-31

Brief Summary

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Capturing the earliest stages of Dementia especially Alzheimer's Disease (AD) is a great challenge. Until now the NINCDS-ADRDA and the DSM criteria for AD were largely used as diagnostic standards in research. However, the research on AD progresses and some biomarkers have been recently suggested to improve the diagnostic criteria of AD, such as cerebrospinal fluid markers, neuroimaging with Positon Emission Tomography (PET) or Magnetic Resonance Imaging (MRI).

Detailed Description

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Conditions

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Dementia Alzheimer Disease

Keywords

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dementia Alzheimer's Disease diagnostic biomarkers neuroimaging PET MRI mild cognitive impairment

Study Design

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Observational Model Type

ECOLOGIC_OR_COMMUNITY

Study Time Perspective

PROSPECTIVE

Study Groups

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elderly subjects retired from agriculture

Neuroimaging

Intervention Type OTHER

Three successive MRI acquisitions to measure FA, MTR and T2 parameters.

Interventions

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Neuroimaging

Three successive MRI acquisitions to measure FA, MTR and T2 parameters.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* participate in the AMI cohort
* be aged 65 and older
* be retired from agricultural profession
* live in rural area in Gironde

Exclusion Criteria

* contraindication of MRI
* left-handed
* severe dementia
* Parkinson's disease
* poor health incompatible with the transport to neuroimaging service
* to be left handed
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Bordeaux

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Michèle ALLARD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Bordeaux

Locations

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Groupe Hospitalier Pellegrin - C.H.U. de Bordeaux

Bordeaux, , France

Site Status

Countries

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France

Other Identifiers

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CHUBX2008/13

Identifier Type: -

Identifier Source: org_study_id