Multimodal Imaging in the Study of Disorientation in the Hospital
NCT ID: NCT04387357
Last Updated: 2020-05-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
50 participants
OBSERVATIONAL
2019-10-01
2021-06-30
Brief Summary
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Detailed Description
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Additionally, brain structure and functional connectivity changes associated with different levels of spatial orientation and gait parameters will also be investigated through resting-state functional imaging.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Control
Neurologically healthy older adults above the age of 50
No interventions assigned to this group
Experimental
Older adults above the age of 50 with Mild Cognitive Impairment or Dementia
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Mini mental state examination (MMSE) ≥ 12 \< 28 points for experimental group
* Mini mental state examination (MMSE) ≥ 28 points for control group
* Sufficient knowledge of German to understand participant information, declaration of consent and questionnaires
* Dated and signed declaration of consent
* Sufficient mobility and motivation to participate in the study
Exclusion Criteria
* Significantly impaired vision or hearing
* Severely reduced mobility: cannot move around independently (even with aids)
50 Years
ALL
Yes
Sponsors
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German Center for Neurodegenerative Diseases (DZNE)
OTHER
University Medical Center Rostock
OTHER
Responsible Party
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Stefan Teipel
Prof. Dr. med
Principal Investigators
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Stefan J. Teipel, Prof. Dr.
Role: PRINCIPAL_INVESTIGATOR
University Medical Center Rostock
Locations
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Clinic and Polyclinic for Psychosomatics and Psychotherapeutic Medicine, University Medical Center Rostock
Rostock, Mecklenburg-Vorpommern, Germany
Countries
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Central Contacts
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Facility Contacts
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References
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Schaat S, Koldrack P, Yordanova K, Kirste T, Teipel S. Real-Time Detection of Spatial Disorientation in Persons with Mild Cognitive Impairment and Dementia. Gerontology. 2020;66(1):85-94. doi: 10.1159/000500971. Epub 2019 Jul 30.
Ranasinghe KG, Hinkley LB, Beagle AJ, Mizuiri D, Dowling AF, Honma SM, Finucane MM, Scherling C, Miller BL, Nagarajan SS, Vossel KA. Regional functional connectivity predicts distinct cognitive impairments in Alzheimer's disease spectrum. Neuroimage Clin. 2014 Jul 23;5:385-95. doi: 10.1016/j.nicl.2014.07.006. eCollection 2014.
Other Identifiers
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A-2012-0083
Identifier Type: -
Identifier Source: org_study_id
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