Study of Phosphorylated Metabolism Profile as Predictive Biomarker of Cognitive Decline in Memory Complaint.

NCT ID: NCT03863041

Last Updated: 2023-10-06

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 49 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-04-08
• Study Completion Date: 2023-06-15

Brief Summary

Alzheimer disease is a frequent disease in the late ages that results in global alteration of cognitive functions. In which memory complaint can be isolated in the early stages.

Physiopathology of neuronal degenerescence in Alzheimer disease is complex, two main histological lesions are known, amyloid plaques and neurofibrillar tangles. Beyond the histological knowledge, alterations of neuronal metabolism are described such as oxydative phosphorylation and glycolytic pathway. These metabolism alterations are involved in neuronal death.

Multi-nucleus magnetic resonance spectroscopy is a non-invasive non-irradiant imagery technique already used in routine. This technic allows the phosphoenergetic pool assessment, that inform about cellular metabolism.

The aim of the study is to explore the phosphorylated metabolism patterns as predictive biomarkers of cognitive decline in patients with a memory complaint diagnosed.

Conditions

Memory Complaint; Alzheimer Disease; Phosphorylated Metabolism Profile; Magnetic Resonance Spectroscopy

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

Additional MRI SCAN sequence

Additional sequence performed during MRI scan

Group Type: OTHER

Additional sequence performed during MRI scan

Intervention Type: OTHER

An additional sequence will be performed during the MRI scan.

Interventions

Additional sequence performed during MRI scan

An additional sequence will be performed during the MRI scan.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. Memory complaint, leading to a medical visit at the Centre Mémoire de Ressources et de Recherche (CMRR) of Poitiers, and for which an MRI is needed in routine exploration.

2. Age inferior at 90 years old

3. Mini Mental State Examination (MMSE) score between 20 and 30

4. Patient without guardianship measure, without restricted liberty.

5. Patient who benefits from social security

Exclusion Criteria

1. Vascular, tumor, inflammatory pathology diagnosed by MRI

2. Other diagnosed neurodegenerative disease than Alzheimer disease

3. Other non neurodegenerative neurological disease

4. Vital risk at short term

5. Severe and uncontrolled psychiatric disease

• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Poitiers University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

CHU of Poitiers

Poitiers, , France

Countries

France

Other Identifiers

IRMAPHO

Identifier Type: -

Identifier Source: org_study_id