Early Diagnosis of Alzheimer's Disease: Clinical, Neuropsychological and Neuroimaging Follow-up of a Cohort of Patients With an Isolated Memory Impairment

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-07-31

Study Completion Date

2011-12-31

Brief Summary

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The aim of this project is to follow cohort of patients with aMCI in order to establish whether there are distinct subgroups in terms of evolution or aetiology, with distinct memory profiles and profiles of mesiotemporal atrophy and metabolic change

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Detailed Description

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The syndrome of "amnestic Mild Cognitive Impairment" (aMCI) has been introduced for patients with intact activities of daily living, with a memory complaint and objective memory decline on neuropathological assessment, without significative change in other domains of cognition. Follow-up in these patients shows that the memory impairment may remain stable or improve, while it worsens or extends to other cognitive domains in others, indicating prodromal AD.

Conditions

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Alzheimer's Disease

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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1

Subject control

Group Type OTHER

Neurological and neuropsychological consultation, MRI

Intervention Type OTHER

Neurological and neuropsychological consultation, MRI for the month 0, 18 and 36

2

40 patients before hand include in a program

Group Type EXPERIMENTAL

Neurological and neuropsychological consultation, MRI, Studies in imaging of drip, DNA

Intervention Type OTHER

Neurological and neuropsychological consultation, MRI, Studies in imaging of drip, DNA, months 0/18/36

Interventions

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Neurological and neuropsychological consultation, MRI

Neurological and neuropsychological consultation, MRI for the month 0, 18 and 36

Intervention Type OTHER

Neurological and neuropsychological consultation, MRI, Studies in imaging of drip, DNA

Neurological and neuropsychological consultation, MRI, Studies in imaging of drip, DNA, months 0/18/36

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients beforehand include in the PHRC 2001 study (These patients presented to the inclusion in the PHRC 2001 a qualified board of amnestic Mild Cognitive Impairment \[aMCI\] or light cognitive confusion of type amnestic)
* The patient must be affiliated to an insurance scheme disease to participate in this study

Exclusion Criteria

* For the magnetic resonance imaging: usual contraindications for an examination by MRI: claustrophobia, metal foreign bodies, pacemakers, etc.
* Incapacitated to realize the neuropsychological evaluation because of medical intercurrentes disorders
* Appointment of a guardian

Minimum Eligible Age

50 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No