Cognitive, Morphological and Neurobiological Progressive Aspects in Bipolar Disorders in the Elderly: Toward to a Neurodegenerescence Detection?
NCT ID: NCT02843906
Last Updated: 2016-07-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
180 participants
INTERVENTIONAL
2015-07-31
2018-07-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
SCREENING
NONE
Study Groups
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BD/CD +
Lombar punction, RMI, TEP/FDG, ApoE detection, psychiatric tests, neuropsychological tests
Lombar Punction
cerebrospinal fluid testing at screening and M36
Magnetic Resonance Imaging (MRI)
MRI done at screening and M36
Positron-Emission Tomography (TEP) /(FDG)
TEP/FDG done at screening and M36
Psychiatric tests
Neuropsychological Tests
done at screening, M12, M24 and M36
Apolipoprotein (ApoE) detection
ApoE detection done at screening
BD/CD -
Lombar punction, RMI, TEP/FDG, ApoE detection, psychiatric tests, neuropsychological tests
Lombar Punction
cerebrospinal fluid testing at screening and M36
Magnetic Resonance Imaging (MRI)
MRI done at screening and M36
Positron-Emission Tomography (TEP) /(FDG)
TEP/FDG done at screening and M36
Psychiatric tests
Neuropsychological Tests
done at screening, M12, M24 and M36
Apolipoprotein (ApoE) detection
ApoE detection done at screening
a-MCI
Lombar punction, RMI, TEP/FDG, ApoE detection, psychiatric tests, neuropsychological tests
Lombar Punction
cerebrospinal fluid testing at screening and M36
Magnetic Resonance Imaging (MRI)
MRI done at screening and M36
Positron-Emission Tomography (TEP) /(FDG)
TEP/FDG done at screening and M36
Psychiatric tests
Neuropsychological Tests
done at screening, M12, M24 and M36
Apolipoprotein (ApoE) detection
ApoE detection done at screening
Interventions
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Lombar Punction
cerebrospinal fluid testing at screening and M36
Magnetic Resonance Imaging (MRI)
MRI done at screening and M36
Positron-Emission Tomography (TEP) /(FDG)
TEP/FDG done at screening and M36
Psychiatric tests
Neuropsychological Tests
done at screening, M12, M24 and M36
Apolipoprotein (ApoE) detection
ApoE detection done at screening
Eligibility Criteria
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Inclusion Criteria
* in patient or out-patient at one of the centers participating in the study
* Mini-mental state examination (MMSE) score \> 20 at baseline
* patient with diagnostic of amnestic-Mild Cognitive Impairment
* patients suffering of bipolar disorders type I or II
* in remitted (euthymic) state at baseline
Exclusion Criteria
* history of neurologic disorder
* lifetime history of a severe psychiatric disorder other than bipolar disorders
* current medical problems
* patients treated with electroconvulsive therapy within the past six months
* patients with substance abuse or dependence within the past 12 months
* patients hospitalized without consent
60 Years
80 Years
ALL
No
Sponsors
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University Hospital, Tours
OTHER
Assistance Publique - Hôpitaux de Paris
OTHER
University Hospital, Marseille
OTHER
Hospices Civils de Lyon
OTHER
Centre Hospitalier Universitaire de Besancon
OTHER
Central Hospital, Nancy, France
OTHER
University Hospital, Clermont-Ferrand
OTHER
Versailles Hospital
OTHER
University Hospital, Montpellier
OTHER
Reims University hospital
OTHER
Centre Hospitalier Princesse Grace
OTHER
University Hospital, Grenoble
OTHER
Responsible Party
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Principal Investigators
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BOUGEROL BT Thierry, Professor
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Grenoble
Locations
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University Hospital, Tours
Tours, , France
Countries
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Central Contacts
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Facility Contacts
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Camus CV Vincent, Professor
Role: primary
References
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Other Identifiers
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38RC13.217
Identifier Type: -
Identifier Source: org_study_id
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