Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

65 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-01-31

Study Completion Date

2013-04-30

Brief Summary

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In the present clinical study including chronic, aggressive periodontitis and healthy individuals, the investigators aimed to determine the RANKL, osteoprotegrin (OPG), Interleukin-1 (IL-1β), IL-10, IL-1β levels in gingival crevicular fluid(GCF) before and after surgical periodontal treatment and search out the relationship of clinical parameters with these cytokine levels.

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Detailed Description

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Conditions

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Chronic Periodontitis Aggressive Periodontitis RANKL/OPG Ratio Gingival Crevicular Fluid

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Chronic periodontitis

Surgical periodontal treatment and GCF collection 3 months after treatment

No interventions assigned to this group

Agressive periodontitis

Surgical periodontal treatment and GCF collection 3 months after treatment.

No interventions assigned to this group

Control group

Periodontally healthy individuals

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Chronic periodontitis having at least 5mm or more probing depth and aggressive periodontitis patients.

Exclusion Criteria

* Any known systemic disorder, used antibiotics and/or anti-inflammatory medications, had periodontal treatment in the last 3 months and all of them were non smokers. Subjects who were lactating and pregnant were also excluded.

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes