Relationship Between Malocclusion Severity and Periodontitis Risk
NCT ID: NCT07127744
Last Updated: 2025-08-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
NOT_YET_RECRUITING
70 participants
OBSERVATIONAL
2025-09-15
2026-01-19
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
The main question it aims to answer is:
Does increasing severity of orthodontic malocclusion contribute to a higher risk of periodontitis through changes in RANKL/OPG balance and oxidative stress levels?
Participants with different levels of tooth misalignment (malocclusion) will be examined to assess the condition of their teeth and gums. During this examination, information such as dental plaque, gum bleeding, and the depth of gum pockets will be recorded. In addition, fluid samples collected from the gums will be tested in the laboratory to measure certain biological substances and chemical markers related to the body's balance between harmful and protective effects. These measurements will be done using special laboratory tests.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System
NCT02190773
Biochemical Evaluation of Periodontal Effects of Orthodontic Treatment with Aligners
NCT06646705
Relationship Between Periodontal Disease and Postmenopausal Osteoporosis
NCT07294105
Gingival Crevicular Fluid Levels of Sclerostin, Osteoprotegerin (OPG) and RANKL in Health, Disease and After Treatment
NCT02390479
Evaluation of Oxidative Stress and Methylated Arginine Levels in Individuals With Periodontitis
NCT06973148
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
This cross-sectional study will include individuals with varying degrees of malocclusion severity. Orthodontic status will be determined through clinical evaluation and standardized indices, while periodontal status will be assessed using parameters such as the plaque index, papillary bleeding index, and probing pocket depth. In addition, gingival crevicular fluid (GCF) samples will be collected from participants to measure levels of RANKL, OPG, total antioxidant capacity (TAC), and total oxidative status (TOS) using the ELISA method.
The data obtained will help reveal whether orthodontic abnormalities increase the risk of periodontal disease and how this risk correlates with biomarker levels. The study emphasizes the importance of a holistic evaluation of both orthodontic and periodontal health.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
CASE_ONLY
CROSS_SECTIONAL
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Patients with normal or minor malocclusion
Patients with a Dental Aesthetic Index Score of ≤25
No interventions assigned to this group
Moderate malocclusion
Patients with a Dental Aesthetic Index Score of 26-30
No interventions assigned to this group
Severe malocclusion
Patients with a Dental Aesthetic Index Score of 31-35
No interventions assigned to this group
Obstructive malocclusion
Patients with a Dental Aesthetic Index Score ≥ 36
No interventions assigned to this group
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Patients with all permanent teeth,
* Not having taken antibiotics, steroids, and/or nonsteroidal anti-inflammatory drugs in the last 3 weeks,
* Not having an active infectious disease,
* Not having chronic medication use that affects periodontal tissues (cyclosporine A, Phenytoin),
* Not having taken antioxidant supplements in the last 6 months.
Exclusion Criteria
* Patients who have previously started or completed orthodontic treatment,
* Patients who have received periodontal treatment in the last 6 months,
* Acute illness,
* Systemic illness, mental illness, immunosuppressive medications, or immunodeficiency.
12 Years
18 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Recep Tayyip Erdogan University Training and Research Hospital
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Dilek KARADOĞAN
Assoc. Prof. Dr.
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Department of Periodontology of the Faculty of Dentistry of Recep Tayyip Erdogan University
Rize, Rize Province, Turkey (Türkiye)
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
RTEU Faculty of Dentistry, Department of Periodontology
Role: primary
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
periortho05/2025
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.