Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
92 participants
OBSERVATIONAL
2013-12-31
2016-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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OTHER
CROSS_SECTIONAL
Study Groups
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Monozygotic twin pairs
15 monozygotic twin pairs discordant for obesity
No interventions assigned to this group
Genetic predisposition for obesity
15 obese and 15 non-obese individuals with a high genotype obesity risk score and 15 obese and 15 non-obese individuals with a low genotype obesity risk score. Genotype obesity risk score will be based on genome wide association single-nucleotide polymorphisms (SNP's) associated with obesity.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Male or female
* Stable bodyweight (\<5% reported weight change during previous 3 months)
* Women: regular menstruation cycle (to exclude possible menstruation cycle effects)
* Normal fasting blood glucose
Exclusion Criteria
* Known diabetes or abnormal fasting blood glucose
* Serious heart, pulmonary, hepatic or renal disease, malignant or hematological disease
* Metabolic disorders (uncontrolled adrenal/thyroid disease)
* Women: irregular menstruation cycle
* Neurological or psychiatric illness
* Pregnancy or breast feeding
* Alcohol abuse
* Nicotine abuse
* Claustrophobia or metal implants
* Visual disability
* Participation in another study
* Inability to understand the protocol or to give informed consent
* Current/chronic use of following medication: antihyperglycemic agents, glucocorticoids, centrally acting drugs, cytostatics, immune suppressants, potentially addictive medications.
18 Years
75 Years
ALL
Yes
Sponsors
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Amsterdam UMC, location VUmc
OTHER
Responsible Party
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RG IJzerman
MD PhD FRCPE, Professor of Internal Medicine, Chair of Diabetology, Director of Diabetes Center VUmc
Locations
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VU University Medical Center
Amsterdam, , Netherlands
Countries
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References
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Doornweerd S, De Geus EJ, Barkhof F, Van Bloemendaal L, Boomsma DI, Van Dongen J, Drent ML, Willemsen G, Veltman DJ, IJzerman RG. Brain reward responses to food stimuli among female monozygotic twins discordant for BMI. Brain Imaging Behav. 2018 Jun;12(3):718-727. doi: 10.1007/s11682-017-9711-1.
Doornweerd S, IJzerman RG, van der Eijk L, Neter JE, van Dongen J, van der Ploeg HP, de Geus EJ. Physical activity and dietary intake in BMI discordant identical twins. Obesity (Silver Spring). 2016 Jun;24(6):1349-55. doi: 10.1002/oby.21475. Epub 2016 Apr 23.
Other Identifiers
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NL 44735.029.13
Identifier Type: OTHER
Identifier Source: secondary_id
91613082
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
DC2013ObesiBrain001
Identifier Type: -
Identifier Source: org_study_id
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