Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
122 participants
OBSERVATIONAL
2010-08-31
2015-08-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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FAMILY_BASED
PROSPECTIVE
Study Groups
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27 Monozygotic Pairs
Functional Magnetic Resonance Imaging
Measure brain activity.
Dual Energy X-ray absorptiometry
Body composition measurements.
Questionnaires
Questionnaires related to: health, weight, sleep, mood, dietary habits, attitudes towards eating, how you describe yourself.
Mood and Appetite Ratings
Answer questions about how you are feeling at the moment.
Test Meals
Breakfast, a snack, and lunch provided during study visit.
Computer Tests
Perform a series of computer tests to determine reaction time.
Intravenous Catheter (IV) placement
Blood samples collected throughout regular intervals during the study visit day to measure levels of hormones involved in regulating appetite and body weight. We will also determine if twins are fraternal or identical and will examine DNA to see if participants carry two genes that affect appetite or body weight, the FTO gene and the MC4R gene.
27 Dizygotic Pairs
Functional Magnetic Resonance Imaging
Measure brain activity.
Dual Energy X-ray absorptiometry
Body composition measurements.
Questionnaires
Questionnaires related to: health, weight, sleep, mood, dietary habits, attitudes towards eating, how you describe yourself.
Mood and Appetite Ratings
Answer questions about how you are feeling at the moment.
Test Meals
Breakfast, a snack, and lunch provided during study visit.
Computer Tests
Perform a series of computer tests to determine reaction time.
Intravenous Catheter (IV) placement
Blood samples collected throughout regular intervals during the study visit day to measure levels of hormones involved in regulating appetite and body weight. We will also determine if twins are fraternal or identical and will examine DNA to see if participants carry two genes that affect appetite or body weight, the FTO gene and the MC4R gene.
Interventions
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Functional Magnetic Resonance Imaging
Measure brain activity.
Dual Energy X-ray absorptiometry
Body composition measurements.
Questionnaires
Questionnaires related to: health, weight, sleep, mood, dietary habits, attitudes towards eating, how you describe yourself.
Mood and Appetite Ratings
Answer questions about how you are feeling at the moment.
Test Meals
Breakfast, a snack, and lunch provided during study visit.
Computer Tests
Perform a series of computer tests to determine reaction time.
Intravenous Catheter (IV) placement
Blood samples collected throughout regular intervals during the study visit day to measure levels of hormones involved in regulating appetite and body weight. We will also determine if twins are fraternal or identical and will examine DNA to see if participants carry two genes that affect appetite or body weight, the FTO gene and the MC4R gene.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Additional Criteria for Aim 1 random sample only: Member of randomly selected MZ pair or
* Additional criteria for Aim 2 random sample only: One member of MZ or same-sex DZ pair with BMI of at least 30 kg/m\^2
* Additional criteria for Aim 3 sample only: Member of randomly selected MZ pair, and not BMI discordant ≥ 5 kg/m\^2
Exclusion Criteria
* Major medical problem (e.g., diabetes, cancer)
* Current use of weight loss medications or other medications known to alter appetite
* Pregnancy or menopause
* MRI contraindication (i.e., implanted metal, claustrophobia)
* Lifetime eating disorder
* Current smoking
* Current heavy alcohol use (≥2 drinks per day for females and ≥ 3 drinks per day for males)
* Self-reported weight \>330 pounds at time of phone screening. MRI cannot accommodate all shapes or weights. Inability to have MRI does not exclude subject from participating in other study procedures.
* BMI \< 18.5 or \> 45 kg/m\^2
* Allergies to study foods or inability to taste
* Twins were raised apart
* Co-twin not eligible or not willing to participate
18 Years
50 Years
ALL
Yes
Sponsors
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Fred Hutchinson Cancer Center
OTHER
Columbia University
OTHER
University of Washington
OTHER
Responsible Party
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Ellen Schur, MD, MS
Associate Professor, Medicine
Principal Investigators
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Ellen Schur, MD, MS
Role: PRINCIPAL_INVESTIGATOR
University of Washington
Locations
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University of Washington
Seattle, Washington, United States
Countries
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References
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Melhorn SJ, Askren MK, Chung WK, Kratz M, Bosch TA, Tyagi V, Webb MF, De Leon MRB, Grabowski TJ, Leibel RL, Schur EA. FTO genotype impacts food intake and corticolimbic activation. Am J Clin Nutr. 2018 Feb 1;107(2):145-154. doi: 10.1093/ajcn/nqx029.
Mestre ZL, Melhorn SJ, Askren MK, Tyagi V, Gatenby C, Young L, Mehta S, Webb MF, Grabowski TJ, Schur EA. Effects of Anxiety on Caloric Intake and Satiety-Related Brain Activation in Women and Men. Psychosom Med. 2016 May;78(4):454-64. doi: 10.1097/PSY.0000000000000299.
Melhorn SJ, Mehta S, Kratz M, Tyagi V, Webb MF, Noonan CJ, Buchwald DS, Goldberg J, Maravilla KR, Grabowski TJ, Schur EA. Brain regulation of appetite in twins. Am J Clin Nutr. 2016 Feb;103(2):314-22. doi: 10.3945/ajcn.115.121095. Epub 2016 Jan 6.
Related Links
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UW Twin Registry
Other Identifiers
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38970
Identifier Type: -
Identifier Source: org_study_id