A Neurocognitive Model of Anorexia Nervosa

NCT ID: NCT00325520

Last Updated: 2014-08-15

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 152 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2006-05-31
• Study Completion Date: 2014-05-31

Brief Summary

The purpose of this study is to investigate thought processes and neural mechanisms that may contribute to the development of habitual behaviors. The investigators hypothesize that patients with AN will perform differently than people without eating disorders on a series of neuropsychological tasks and will show different neural activation patterns in functional neuroimaging scans.

Detailed Description

Patients with Anorexia Nervosa (AN) have extreme difficulty changing their eating behavior, even when they express desire for change. These behaviors seem to override all other potential responses, and can appear perseverative, or habitual. The purpose of this study is to investigate thought processes and neural mechanisms that may contribute to the development of habitual behaviors. The investigators hypothesize that patients with AN will perform differently than people without eating disorders on a series of neuropsychological tasks and will show different neural activation patterns in functional neuroimaging scans.

Conditions

Anorexia Nervosa

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Anorexia nervosa

Individuals with anorexia nervosa receiving inpatient treatment

No interventions assigned to this group

Healthy controls

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• DSM-IV-TR™ diagnosis of anorexia nervosa (restricting or binge-purge subtype), current or prior;
• Age 16-45;
• Inpatient on GCRU
• Medically stable.

Exclusion:

• Any other current major Axis I disorder (including current bulimia nervosa), except major depression;
• History of concussion, seizure disorder, or other neurological illness;
• History of learning disability;
• Acute Suicidality

Healthy comparison group:

Inclusion:

• No current or past psychiatric illness;
• Age 16-45
• No history of binge eating or vomiting;
• Normal weight (80%-120% ideal body weight)

Exclusion:

• Significant medical or neurologic illness(concussion, seizure disorder, learning disability, other neurological illness)
• Current psychotropic medication or medications known to impact cognition

Exclusion Criteria

• Significant Claustrophobia
• Pregnancy
• Indwelling metallic object, non-removable metal jewelry, medicinal patch or recent metallic ink tattoo
• For patients, current psychotropic medications (antidepressants for 2 week (prozac and antipsychotics for 4 weeks)
• For patients, any other current Axis I diagnosis

• Minimum Eligible Age: 16 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Klarman Family Foundation

UNKNOWN

Sponsor Role: collaborator

National Institute of Mental Health (NIMH)

NIH

Sponsor Role: collaborator

New York State Psychiatric Institute

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Joanna Steinglass, MD

Role: PRINCIPAL_INVESTIGATOR

New York State Psychiatric Institute

Other Identifiers

K23MH076195-01A2

Identifier Type: NIH

Identifier Source: secondary_id

View Link

#5984R

Identifier Type: -

Identifier Source: org_study_id