Reward Systems and Food Avoidance in Eating Disorders

NCT ID: NCT02795455

Last Updated: 2025-05-07

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 90 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-11-30
• Study Completion Date: 2021-07-29

Brief Summary

The researchers plan to explore brain networks involved in emotion processing and learning using a brain scan and test meals. One core feature of Anorexia Nervosa (AN) is eating a small number of high-calorie or high-fat foods. By studying why individuals with AN are disgusted by food or other eating situations, the researchers will be able to understand more about the neurobiological pathways that lead to restricting food intake and food avoidance. This study also aims to find whether one of two short-term interventions (Interoceptive Exposure (IE); Family-Based Therapy (FBT)) affects connections in the brain and if the treatments affect food avoidance. IE is an intervention that helps reduce anxiety about eating. FBT is an intervention that motivates patients to eat through working with family to increase the value of eating and decrease the value of avoiding foods.

Detailed Description

Anorexia nervosa (AN), a characteristically relentless pursuit of thinness with an intense fear of weight gain despite significantly low body weight, is a serious psychiatric disorder with high rates of morbidity and mortality. Low weight eating disorders (LW-ED), the broader category of eating pathology that includes AN and similar variants, are characterized by a chronic course, poor response to treatment, and food avoidance. Emerging neuroimaging evidence suggests that deficits in insula-amygdala-ventral striatum (IAVS) neurocircuitry contribute to individual variability in aversive and reward learning, and that these brain regions demonstrate abnormal responses to food/eating stimuli. The researchers' pilot data suggest that patients with LW-ED experience difficulty extinguishing food-cue associations in a reversal learning paradigm compared to healthy controls, a difficulty that is related to psychophysiological measures of aversive disgust (not fear). The researchers have also successfully piloted an interoceptive exposure intervention for this population that targets visceral sensitivity and seeks to increase 'top-down' regulation of the IAVS neurocircuit. The proposed project will (a) use novel fMRI-EMG to test the relationship between effective connectivity within amygdala-insula-ventral striatum network and its relationship to psychophysiological and behavioral measures of acute threat and reward learning in 60 adolescents with LWEDs and 30 healthy controls, (b) test the sensitivity of this network to an experimental interoceptive exposure paradigm relative to patients receiving family based therapy for weight restoration using dynamic causal modeling of fMRI-EMG data pre-post experimental conditions, (c) validate this model against objective measures of laboratory and real world eating behavior. The results of this study will help better understand the core neurocircuitry that underlies both threat processing and reward/aversive learning and how this circuit relates to objective behavior. Further, the researchers will determine the modifiability of this neurocircuitry via two distinct behavioral interventions chosen to target different aspects of affective processing and reward learning. These data will be used to inform future clinical interventions targeting aversive/reward learning within this population and dysregulation in insula-amygdala-ventral striatum subcircuits.

Conditions

Low Weight Eating Disorders; Anorexia Nervosa

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Interoceptive Exposure (IE)

IE is an exposure-based intervention that involves consuming a food in session and tolerating uncomfortable feelings around eating.

Group Type: EXPERIMENTAL

Interoceptive Exposure (IE)

Intervention Type: BEHAVIORAL

Participants are provided with a meal replacement shake of 'unknown' Kcal or macronutrient content and are asked to mindfully observe the sensations (aversive taste, texture, bloating, icky feeling, etc.) and associated emotional states (i.e., disgust) with the empathetic support of parents/therapist in session, without expectation of habituation. Sessions occur on a weekly basis with session one lasting 2 hrs. The remaining 5 sessions last one hour, and participants eat a meal replacement shake over 30-minutes, identical to the first session. All sessions include debriefing and development of IE homework that includes daily practice of IE.

meal replacement shake

Intervention Type: DIETARY_SUPPLEMENT

Family Based Therapy-Weight Gain Control (FBT-WG)

Family-based therapy uses parent(s) to help modify disordered eating and develop contingencies to motivate eating.

Group Type: ACTIVE_COMPARATOR

Family Based Therapy-Weight Gain Control (FBT-WG)

Intervention Type: BEHAVIORAL

Participants and families randomized to FBT-WG will receive 6-weeks of FBT treatment for AN. Sessions occur weekly, with the first session lasting two hours and the remaining 5 sessions one hour. FBT is atheoretical in terms of the etiology, but uses parent-enforced contingencies to increase value of eating and decrease the value of food avoidance.

Healthy Controls (HC)

HC participants will only participate in the pre and post-intervention visits and not in the intervention sessions.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Interoceptive Exposure (IE)

Participants are provided with a meal replacement shake of 'unknown' Kcal or macronutrient content and are asked to mindfully observe the sensations (aversive taste, texture, bloating, icky feeling, etc.) and associated emotional states (i.e., disgust) with the empathetic support of parents/therapist in session, without expectation of habituation. Sessions occur on a weekly basis with session one lasting 2 hrs. The remaining 5 sessions last one hour, and participants eat a meal replacement shake over 30-minutes, identical to the first session. All sessions include debriefing and development of IE homework that includes daily practice of IE.

Intervention Type: BEHAVIORAL

Family Based Therapy-Weight Gain Control (FBT-WG)

Participants and families randomized to FBT-WG will receive 6-weeks of FBT treatment for AN. Sessions occur weekly, with the first session lasting two hours and the remaining 5 sessions one hour. FBT is atheoretical in terms of the etiology, but uses parent-enforced contingencies to increase value of eating and decrease the value of food avoidance.

Intervention Type: BEHAVIORAL

meal replacement shake

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

• Females,
• Adolescents ages 12-18,
• Speak English,
• Seeking treatment
• Refusal to maintain greater than minimally low body weight based on BMI for age percentiles and growth trajectories,
• Clinically significant restriction of food intake on the dietary restraint subscale of the EDE or evidence of persistent food avoidance as reported by patient or guardians.
• Given medical clearance from pediatrician or equivalent.

• Females,
• Adolescents ages 12-18,
• Speak English.

Exclusion Criteria

• Current psychotropic medication that would have an effect on performance on behavioral tasks (i.e., anti-anxiety medication),
• Comorbid psychotic or bipolar disorder,
• Active suicidal ideation,
• Major medical illness known to influence eating or weight,
• Current substance dependence,
• Previous exposure therapy for LW-ED.
• Physical limitation that would prevent participation (e.g., allergic to chocolate),
• For patients with current or a history of sexual or physical abuse by parents, siblings, or guardians, perpetrators of the abuse will be excluded from treatment; if physical or sexual abuse by a family member occurs during the course of treatment, perpetrators will be excluded from ongoing treatment

Healthy Comparison Adolescents

• Current psychotropic medication that would have an effect on performance on behavioral tasks (i.e., stimulant medication),
• Current or lifetime history of any psychiatric disorder, including eating disorders by K-SADS,
• Current or lifetime history of learning disorder or developmental disability
• Active suicidal ideation,
• Major medical illness,
• Other physical limitation that would prevent participation (e.g., allergic to chocolate).

• Minimum Eligible Age: 12 Years
• Maximum Eligible Age: 18 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

National Institute of Mental Health (NIMH)

NIH

Sponsor Role: collaborator

Icahn School of Medicine at Mount Sinai

OTHER

Sponsor Role: lead

Responsible Party

Tom Hildebrandt

Associate Professor - Psychiatry

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Tom Hildebrandt, PsyD

Role: PRINCIPAL_INVESTIGATOR

Icahn School of Medicine at Mount Sinai

Locations

Icahn School of Medicine at Mount Sinai

New York, New York, United States

Countries

United States

References

Schulz KP, Sysko R, Fan J, Hildebrandt TB. Interoceptive Exposure Impacts Food-Cue Extinction in Adolescents With Low-Weight Eating Disorders: A Functional Magnetic Resonance Imaging Study. J Am Acad Child Adolesc Psychiatry. 2025 Feb 25:S0890-8567(25)00106-6. doi: 10.1016/j.jaac.2024.12.013. Online ahead of print.

Reference Type: BACKGROUND

PMID: 40015474 (View on PubMed)

Hildebrandt T, Schulz K, Fleysher L, Griffen T, Heywood A, Sysko R. Development of a methodology to combine fMRI and EMG to measure emotional responses in patients with anorexia nervosa. Int J Eat Disord. 2018 Jul;51(7):722-729. doi: 10.1002/eat.22893. Epub 2018 Aug 18.

Reference Type: DERIVED

PMID: 30120839 (View on PubMed)

Provided Documents

Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

1R01MH109639-01A1

Identifier Type: NIH

Identifier Source: secondary_id

View Link

GCO 15-0939

Identifier Type: -

Identifier Source: org_study_id