Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
112 participants
INTERVENTIONAL
2010-05-31
2013-05-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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CBT (Cognitive Behavioral Therapy)
Investigates the effects of cognitive-behavioral therapy (CBT), on the secretion of brain dopamine (DA), noradrenalin (NE) and serotonin (5-HT) in a group of 50 female inpatients, 14 with AN restricter type (AN-R), 14 with the bingeing-purging type (AN-BP), and 22 with BN.
Associated intervention (non of interest): psychiatric management (with tranquillizer: delorazepam), nutritional rehabilitation
CBT (Cognitive Behavioral Therapy)
It is a worldwide known form of psychotherapy for eating disorders
nutritional rehabilitation
all patients were followed-up monthly with nutritionist and dietitian visits
delorazepam
all patients were followed-up with psychiatric visits with symptomatic drug administration (tranquillizer: delorazepam) where necessary
IBPP (IP brief psychotherapy )
Investigates the effects in 15 AN and 17 BN patients of an individual psychology brief psychotherapy (IBPP) on psychological alterations and DA secretion measured as peripheral blood values of HVA before and after treatment.
Associated intervention (non of interest): psychiatric management (with tranquillizer: delorazepam), nutritional rehabilitation.
IBPP (individual psychology brief psychotherapy)
It is a worldwide known form of psychotherapy for eating disorders
nutritional rehabilitation
all patients were followed-up monthly with nutritionist and dietitian visits
delorazepam
all patients were followed-up with psychiatric visits with symptomatic drug administration (tranquillizer: delorazepam) where necessary
CBT + OLANZAPINE (5 MG)
The study evaluated in 18 AN-R and 12 AN-BP patients the effects of CBT and of CBT associated with orally administered 5 mg olanzapine on the psychopathological aspects of the disease and on the secretion of HVA.
Associated intervention (non of interest): psychiatric management (with tranquillizer: delorazepam), nutritional rehabilitation
CBT + OLANZAPINE
It is a worldwide known form of psychotherapy for eating disorders associated with a new antipsychotic with good efficacy on anorexia nervosa
nutritional rehabilitation
all patients were followed-up monthly with nutritionist and dietitian visits
delorazepam
all patients were followed-up with psychiatric visits with symptomatic drug administration (tranquillizer: delorazepam) where necessary
Interventions
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CBT (Cognitive Behavioral Therapy)
It is a worldwide known form of psychotherapy for eating disorders
IBPP (individual psychology brief psychotherapy)
It is a worldwide known form of psychotherapy for eating disorders
CBT + OLANZAPINE
It is a worldwide known form of psychotherapy for eating disorders associated with a new antipsychotic with good efficacy on anorexia nervosa
nutritional rehabilitation
all patients were followed-up monthly with nutritionist and dietitian visits
delorazepam
all patients were followed-up with psychiatric visits with symptomatic drug administration (tranquillizer: delorazepam) where necessary
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* age between 15 and 35
* female gender
Exclusion Criteria
* mental retardation
15 Years
35 Years
FEMALE
No
Sponsors
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University of Milan
OTHER
University of Turin, Italy
OTHER
Responsible Party
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Federico Amianto
Dottor
Principal Investigators
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Federico Amianto, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Torino
Secondo Fassino, MD
Role: STUDY_CHAIR
University of Torino
Locations
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Villa Garda
Garda, Veneto, Italy
Countries
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References
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Brambilla F, Amianto F, Dalle Grave R, Fassino S. Lack of efficacy of psychological and pharmacological treatments of disorders of eating behavior: neurobiological background. BMC Psychiatry. 2014 Dec 24;14:376. doi: 10.1186/s12888-014-0376-7.
Other Identifiers
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Brambilla trial
Identifier Type: -
Identifier Source: org_study_id