Impact of Neuropsychological Alteration of Decision-making Abilities on the Functioning of Patients With Eating Disorders

NCT ID: NCT03160443

Last Updated: 2021-12-21

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 340 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-05-03
• Study Completion Date: 2022-07-30

Brief Summary

Eating disorders are multifactorial disorders currently conceptualized in a biopsychosocial model, but pathophysiology remains relatively unknown, and robust etiological models to guide treatment are therefore lacking. Different endophenotypes and neurocognitive vulnerability factors have been found in eating disorders including decision making abnormalities. The investigators hypothesize that decision making abnormalities are associated with a lower level of functioning and quality of life which could lead to social and interpersonal difficulties. The investigators also hypothesize that these anomalies are associated with a particular clinical profile (more restrictive profile, more hyperactivity, less insight on the disease and desire for care ...).

Detailed Description

The investigators will recruit a total of 340 patients with an eating disorder in the university hospital of Montpellier.

• Participation consists of a one-day visit with a multidisciplinary assessment. No action is specific to research. This is the usual management of patients with eating disorders addressed to our department.
• An ancillary study will be proposed, if the patient is addressed by his general practitioner for an annual evaluation. This second visit will be exactly the same as the initial visit.

Conditions

Eating Disorder

Keywords

Anorexia nervosa; Bulimia; Binge eating disorders; Neuropsychology; Neurocognition; Daily functioning

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Participants

All participants performed the same evaluation: clinical and neuropsychological assessment.

All of them are patients with an eating disorder.

Group Type: OTHER

Ambulatory cares in a day-hospital (University Hospital of Montpellier) specialized in the evaluation of eating disorders

Intervention Type: BEHAVIORAL

All patients assessed in the day-hospital will performed the same evaluation :

• Blood sampling
• Calorimetry
• Osteodensitometry
• Psychiatric assessment
• Endocrinologic assessment
• Dietetic assessment
• Neuropsychological assessment
• Self-questionnaires

With the patient agreement, a biological collection will be constituted. The objective is the subsequent study of biological factors involved in eating disorders (in particular genetic factors)

Interventions

Ambulatory cares in a day-hospital (University Hospital of Montpellier) specialized in the evaluation of eating disorders

All patients assessed in the day-hospital will performed the same evaluation :

• Blood sampling
• Calorimetry
• Osteodensitometry
• Psychiatric assessment
• Endocrinologic assessment
• Dietetic assessment
• Neuropsychological assessment
• Self-questionnaires

With the patient agreement, a biological collection will be constituted. The objective is the subsequent study of biological factors involved in eating disorders (in particular genetic factors)

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Patient with an eating disorder according to Diagnostic and Statistical Manuel of Mental disorders-V (DSM-V) criteria
• Patient aged from 15 to 65 years
• Patient who performs the day-hospital evaluation
• Patient affiliated to a French social security system
• Patient able to understand the nature, the aim and the methodology of the study
• For minor one of the legal guardians gave his consent

Exclusion Criteria

• Patient in an unstable somatic state (eg severe metabolic disorder making impossible or unreliable neuropsychological assessments)
• Patient's refusal to participate
• Patient on protective measures (guardianship or trusteeship)
• Pregnant or nursing women. A dosage of beta human chorionic gonadotropin (βHCG) will be performed to ensure the absence of pregnancy.

• Minimum Eligible Age: 15 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

INSERM 1061, " Neuropsychiatry: epidemiological and clinical research", Montpellier

UNKNOWN

Sponsor Role: collaborator

University Hospital, Montpellier

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Hôpital Lapeyronie

Montpellier, , France

Countries

France

Other Identifiers

9804

Identifier Type: -

Identifier Source: org_study_id