Brain Function in Adolescent Eating Disorders and Healthy Peers

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

155 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-07-21

Study Completion Date

2025-11-30

Brief Summary

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This study of adolescent eating disorders (ED) will examine the association of temperament-based classifications, brain activation during incentive processing, and ED symptoms at time of scan and 1 year later to better understand the neurobiology and symptoms of ED. We will recruit 150 females currently ill with an ED and 50 controls ages 14-17 to investigate how temperaments reflecting greater inhibition, impulsivity, or effortful control correspond to 1) clinical symptoms and 2) the brain's response to anticipation and outcome of salient stimuli, and 3) by collecting follow-up clinical data one year later, identify how temperament-based subtypes predict ED symptom change (e.g., clinical prediction). Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).

Detailed Description

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Conditions

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Eating Disorder

Keywords

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adolescents, healthy controls

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Adolescents with an Eating Disorder

Females between the ages of 14-17 currently diagnosed with an eating disorder (including ARFID, Anorexia Nervosa, Bulimia Nervosa, OSFED)

No interventions assigned to this group

Healthy Controls

Females between the ages of 14-17 with no psychiatric conditions

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Female
* Meet DSM-V criteria for an Eating Disorder or Never met criteria for an Eating disorder
* Medically stable
* Post-Pubertal (must have started menses, but subsequent loss of menses secondary to ED is fine).

Exclusion Criteria

* Psychotic illness/other mental illness requiring hospitalization
* Current dependence on drugs or alcohol
* Physical conditions known to influence eating or weight (e.g, diabetes mellitus, pregnancy).
* On psychoactive medication
* Organic brain syndromes, delirium, psychotic disorders, or intellectual disability
* Neurological or medical disorders such as seizure disorder
* Any contraindication to undergoing an MRI
* Major depressive disorder
* Left handed

Minimum Eligible Age

14 Years

Maximum Eligible Age

17 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Responsible Party

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Christina Wierenga

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of California San Diego

San Diego, California, United States

Site Status

Countries

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United States

Other Identifiers

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170664

Identifier Type: -

Identifier Source: org_study_id