Neural Correlates of Reward and Symptom Expression in Anorexia Nervosa
NCT ID: NCT03275545
Last Updated: 2022-09-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
79 participants
OBSERVATIONAL
2018-02-28
2022-08-01
Brief Summary
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Detailed Description
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Hypothesis 1a: Activity in reward circuitry will be elevated in response to typically rewarding cues in the non-eating disorder control group versus weight-restored anorexia nervosa group.
Hypothesis 1b: Activity in reward circuitry will be elevated in response to disorder-specific in the weight-restored anorexia nervosa group versus the non-eating disorder control group.
Aim 2: To specify the relationship between brain patterns related to reward and restrictive eating among weight-restored individuals with anorexia nervosa
Hypothesis 2a: Lower reward circuit activity in response to typically rewarding cues will predict lower test meal intake for weight-restored anorexia nervosa group versus the non-eating disorder control group.
Hypothesis 2b: Higher reward circuit activity in response to disorder-specific cues will predict lower test meal intake for the weight-restored anorexia nervosa group versus the non-eating disorder control group.
Aim 3: To identify the brain patterns in reward circuitry associated with the risk of relapse among weight-restored individuals with anorexia nervosa in the year following weight-restoration.
Hypothesis 3a: Lower reward circuit activity in response to typically rewarding cues will predict relapse in the weight-restored anorexia nervosa group.
Hypothesis 3b: Higher reward circuit activity in response to disorder-specific cues will predict relapse in the weight-restored anorexia nervosa group.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Anorexia Nervosa, Weight Restored
Individuals with a recent diagnosis of anorexia nervosa (within the past 6 months), who currently have their weight in a healthy range (BMI \> or = 18.5 kg/m2)
No intervention
No intervention is being examined in this study
Non-eating disorder Control
Individuals without a history of an eating disorder and no current DSM-5 psychiatric diagnoses.
No intervention
No intervention is being examined in this study
Interventions
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No intervention
No intervention is being examined in this study
Eligibility Criteria
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Inclusion Criteria
* Current BMI \> 18.5 kg/m2
* Ability to read and speak in English
* Right-handed
* Weight restored Anorexia Nervosa group: 1) DSM-5 diagnosis of AN in the past 6 months, with the exception of body image disturbance and intense fear of weight gain criteria; 2) BMI \< 18.5 kg/m2 within past 6 months
Exclusion Criteria
* Current substance use disorder, psychosis, or bipolar-I disorder
* Contraindication for fMRI
* History of neurological disorder/injury (e.g., stroke; head injury with \> 10 minutes loss of consciousness)
* Food allergy that cannot be accommodated through substitutions to the laboratory test meal
* Lacking capacity to consent
* Non-eating disorder Control group: Current DSM-5 Axis-I diagnosis or current or past eating disorder diagnosis
18 Years
ALL
Yes
Sponsors
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University of Minnesota
OTHER
Responsible Party
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Principal Investigators
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Ann Haynos, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Minnesota
Locations
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University of Minnesota
Minneapolis, Minnesota, United States
Countries
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Other Identifiers
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PSYCH-2017-25878
Identifier Type: -
Identifier Source: org_study_id
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