Avoidance-driven Decision Making and Learning in Anorexia Nervosa and Bulimia Nervosa
NCT ID: NCT06566612
Last Updated: 2024-12-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
78 participants
OBSERVATIONAL
2024-08-01
2027-07-31
Brief Summary
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Aim 1: Evaluate behavioral differences in active and passive avoidance learning in eating disorders and associations with symptoms.
Aim 2: Evaluate whether corticostriatal and limbic-prefrontal fMRI BOLD response associated with avoidance learning differs in eating disorders relative to healthy controls and relates to symptoms.
Aim 3: Evaluate whether functional connectivity of avoidance learning neural circuity differs in eating disorders relative to healthy controls.
Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Anorexia Nervosa
Participants that meet Diagnostic And Statistical Manual Of Mental Disorders (DSM-V) criteria for Anorexia Nervosa.
No interventions assigned to this group
Bulimia Nervosa
Participants that meet DSM-V criteria for Bulimia Nervosa.
No interventions assigned to this group
Healthy Controls
Participants that do not meet DSM-V criteria for any disorder.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Between the ages of 18 and 39 years old
* Meet DSM-V criteria for anorexia nervosa or bulimia nervosa
Healthy Controls:
* Between the ages of 18 and 39 years old
* Have maintained 85% to 120% ideal body weight since menarche
Exclusion Criteria
* Current dependence on drugs or alcohol defined by DSM IV criteria. Additionally, positive test results for drug use on the day of the scan, apart of marijuana, will result in cancelling or rescheduling the scan because acute use will impact MRI measures.
* Physical conditions (e.g. diabetes mellitus, pregnancy) known to influence eating or weight
* Neurological disorder, neurodevelopmental disorder, or history of head injury with \>30 min loss of consciousness
* Any contraindication to undergoing an MRI
* Primary obsessive compulsive disorder or primary major depressive disorder
* If taking other psychotropic medication, any change in dosage in the 2 weeks before scanning
* Meet criteria for the diagnosis of any psychiatric disorder currently
* Any history of binge eating or purging behaviors, including self-induced vomiting, laxative or diuretic misuse
* Use of any psychoactive or other medication known to affect mood or concentration in the last 3 months
18 Years
39 Years
FEMALE
Yes
Sponsors
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University of California, San Diego
OTHER
Responsible Party
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Christina Wierenga
Professor in Residence
Locations
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UCSD Eating Disorders Treatment and Research Program
La Jolla, California, United States
Countries
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Central Contacts
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Facility Contacts
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Sophie R Abber, MS
Role: primary
Katherine Gandee, BS
Role: backup
Christina E Wierenga, PhD
Role: backup
Other Identifiers
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810384
Identifier Type: -
Identifier Source: org_study_id