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An fMRI Study of Self-regulation in Adolescents With Bulimia Nervosa

NCT ID: NCT00345943

Last Updated: 2021-12-02

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

71 participants

Study Classification

OBSERVATIONAL

Study Start Date

2004-10-31

Study Completion Date

2021-08-31

Brief Summary

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The aim of this project is to use both multimodal MRI and behavioral measures to investigate how changes in frontostriatal neural systems contribute to the development and persistence of Bulimia Nervosa (BN). Findings from this study will have wide-ranging importance for our understanding of the development and treatment of BN.

Detailed Description

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Patients with Bulimia Nervosa (BN) have difficulty regulating impulsive behaviors as suggested by their binge-eating and purging, as well as the high incidence of drug abuse and shoplifting in this population. Understanding dysfunction in the frontostriatal circuitry that mediates self-regulatory control processes will aid development of new therapeutics for the impulsivity associated with BN. We are conducting a longitudinal study to better understand the development and persistence of BN.

Participation in this study includes 4 sections: Neuropsychological Tests, Diagnostic interviews, Pregnancy Test, and MRI scan. All efforts are made to coordinate procedures into one day, and they require between 4 and 5 hours of the participant's time. The option of splitting participation into two study days is also offered for participants who find it more convenient. Participants are compensated with $100 in the form of a check, which is mailed to their home address. Participants will be invited back for follow-up visits.

Conditions

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Eating Disorders

Keywords

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Eating Disorders Bulimia Nervosa Bulimia fMRI Magnetic Resonance Imaging

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Adolescents with Bulimia Nervosa or subclinical BN

Adolescents with Bulimia Nervosa or subclinical Bulimia Nervosa

MRI

Intervention Type OTHER

Magnetic Resonance Imaging scans

Neuropsychological Testing

Intervention Type BEHAVIORAL

Neuropsychological tests

Healthy control adolescents

Healthy control adolescents

MRI

Intervention Type OTHER

Magnetic Resonance Imaging scans

Neuropsychological Testing

Intervention Type BEHAVIORAL

Neuropsychological tests

Interventions

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MRI

Magnetic Resonance Imaging scans

Intervention Type OTHER

Neuropsychological Testing

Neuropsychological tests

Intervention Type BEHAVIORAL

Other Intervention Names

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GE 3T scanner Anatomical Images, DTI, and MRS Wechsler Abbreviated Scale of Intelligence (WASI) Continuous Performance Task Stroop Word-Color Interference Weather Prediction Task

Eligibility Criteria

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Inclusion Criteria

* Current or prior DSM IV diagnosis of Bulimia Nervosa or Sub-threshold Bulimia Nervosa (those who meet all DSM-IV criteria for BN, but engage in subjective binge-eating episodes and binge/purge at a frequency of at least once per week for 3 months, whereas meeting full DSM-IV criteria for BN requires binge eating and purging twice per week for 3 months)
* Major Depression
* For control adolescents, no current or past history of an eating disorder

Exclusion Criteria

* Ferromagnetic implants (e.g., pacemaker)
* Metal braces or retainers
* IQ less than 80
* Any other current major Axis I disorder, other than major depressive disorder (MDD)
* History of concussion, seizure disorder, or other neurological illness
* Claustrophobia
* Pregnant
Minimum Eligible Age

12 Years

Maximum Eligible Age

17 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Mental Health (NIMH)

NIH

Sponsor Role collaborator

New York State Psychiatric Institute

OTHER

Sponsor Role lead

Responsible Party

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Rachel Marsh

Research Scientist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Rachel Marsh, PhD

Role: PRINCIPAL_INVESTIGATOR

Columbia University

Locations

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New York State Psychiatric Institute at Columbia University Medical Center

New York, New York, United States

Site Status

Countries

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United States

References

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Berner LA, Wang Z, Stefan M, Lee S, Huo Z, Cyr M, Marsh R. Subcortical Shape Abnormalities in Bulimia Nervosa. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Dec;4(12):1070-1079. doi: 10.1016/j.bpsc.2018.12.011. Epub 2019 Jan 4.

Reference Type DERIVED
PMID: 30846367 (View on PubMed)

Cyr M, Wang Z, Tau GZ, Zhao G, Friedl E, Stefan M, Terranova K, Marsh R. Reward-Based Spatial Learning in Teens With Bulimia Nervosa. J Am Acad Child Adolesc Psychiatry. 2016 Nov;55(11):962-971.e3. doi: 10.1016/j.jaac.2016.07.778. Epub 2016 Sep 8.

Reference Type DERIVED
PMID: 27806864 (View on PubMed)

Marsh R, Maia TV, Peterson BS. Functional disturbances within frontostriatal circuits across multiple childhood psychopathologies. Am J Psychiatry. 2009 Jun;166(6):664-74. doi: 10.1176/appi.ajp.2009.08091354. Epub 2009 May 15.

Reference Type DERIVED
PMID: 19448188 (View on PubMed)

Other Identifiers

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R01MH090062

Identifier Type: NIH

Identifier Source: secondary_id

View Link

DDTR M2-MBB

Identifier Type: -

Identifier Source: secondary_id

#5606R/6679R

Identifier Type: -

Identifier Source: org_study_id