A Clinical Trial Into the Efficacy of rTMS Treatment for Treating Anorexia Nervosa and Bulimia Nervosa
NCT ID: NCT04061304
Last Updated: 2021-10-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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WITHDRAWN
NA
INTERVENTIONAL
2020-06-01
2021-03-19
Brief Summary
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The investigators will also be comparing the brain activity patterns of individuals with Anorexia Nervosa and Bulimia Nervosa to healthy controls using electroencephalography (EEG). Further, the investigators would like to examine if the activation patterns in these patients change after receiving rTMS.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Active rTMS (Anorexia Nervosa)
Patients in this arm will receive 40 sessions of active rTMS. Every day, the first session of rTMS for both groups will be applied to the left DLPFC using intermittent Theta Burst Stimulation (iTBS).
For the second session each day the patients in the anorexia group will receive low-frequency treatment (1 Hz, 60 second cycles, 30 second inter-train interval, 20 trains, 1200 total pulses) at 120% of the resting motor threshold to the orbitofrontal cortex
Repetitive Transcranial Magnetic Stimulation
A non-invasive method of brain stimulation.
Active rTMS (Bulimia Nervosa)
Patients in this arm will receive 40 sessions of active rTMS. Every day, the first session of rTMS for both groups will be applied to the left DLPFC using intermittent Theta Burst Stimulation (iTBS).
For the second session each day the patients in the bulimia group will receive high-frequency (10 Hz, 5 second cycles, 50 pulses, 25 second inter-train interval, 60 trains, 3000 total) at 120% of the resting motor threshold treatment to the left dorsomedial prefrontal cortex
Repetitive Transcranial Magnetic Stimulation
A non-invasive method of brain stimulation.
Sham rTMS (Anorexia Nervosa)
Patients in this arm will receive 40 sessions of sham rTMS. They will be set up the same as the active Anorexia Nervosa group however their will be no actual brain stimulation.
Sham Transcranial Magnetic Stimulation
A device designed to look, sound, and feel like a real magnetic stimulation coil without actually stimulating the brain.
Sham rTMS (Bulimia Nervosa)
Patients in this arm will receive 40 sessions of sham rTMS. They will be set up the same as the active Bulimia Nervosa group however their will be no actual brain stimulation.
Sham Transcranial Magnetic Stimulation
A device designed to look, sound, and feel like a real magnetic stimulation coil without actually stimulating the brain.
Interventions
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Repetitive Transcranial Magnetic Stimulation
A non-invasive method of brain stimulation.
Sham Transcranial Magnetic Stimulation
A device designed to look, sound, and feel like a real magnetic stimulation coil without actually stimulating the brain.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Any rTMS counter-indications:
* History of seizures
* Metal in head
* Currently pregnant
* Having received rTMS for any reason in the past as this would interfere with participant blinding.
18 Years
65 Years
ALL
Yes
Sponsors
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University of Manitoba
OTHER
Responsible Party
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Principal Investigators
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Mandana Modirrousta, MD PhD FRCPC
Role: PRINCIPAL_INVESTIGATOR
University of Manitoba
Other Identifiers
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HS22828 (B2019:033)
Identifier Type: -
Identifier Source: org_study_id
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