Serotonin Role on Brain Circuits Involved in Food Avoidance in Anorexia Nervosa
NCT ID: NCT05155280
Last Updated: 2026-02-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
NA
57 participants
INTERVENTIONAL
2021-12-10
2025-07-08
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Anorexia Nervosa patients
30 patients with anorexia nervosa = 15 with moderate to high anxiety (STAI YB anxiety (STAI YB \> 51) and 15 with low anxiety (STAI YB\<51).
A TOBII eye tracker will be realised at Day 1. PET and MRI scans will be acquired at Day 2.
PET imaging using [11C]DASB radioligand.
Subjects will be asked to complete a food choice task in PET/MRI. During the task, PET and MRI scans will be acquired simultaneously. This will allow us to see in real time during food choices the brain activations of the subjects. For imaging we will inject the DASB tracer intravenously. This radio ligand is a tracer that allows us to see the cerebral serotoninergic transmission by positron emission tomography.
Eye Tracker
The second technique used is the eye tracker that will allow us to analyze food avoidance behaviors through the eyes. With a "TOBII" eye tracker we wil be able to follow the gaze of the subjects during the food preference task. It is a non-invasive approach.
Controls
15 healthy volunteers (control group) and a low level of anxiety trait (\< 51) A TOBII eye tracker will be realised at Day 1. PET and MRI scans will be acquired at Day 2.
PET imaging using [11C]DASB radioligand.
Subjects will be asked to complete a food choice task in PET/MRI. During the task, PET and MRI scans will be acquired simultaneously. This will allow us to see in real time during food choices the brain activations of the subjects. For imaging we will inject the DASB tracer intravenously. This radio ligand is a tracer that allows us to see the cerebral serotoninergic transmission by positron emission tomography.
Eye Tracker
The second technique used is the eye tracker that will allow us to analyze food avoidance behaviors through the eyes. With a "TOBII" eye tracker we wil be able to follow the gaze of the subjects during the food preference task. It is a non-invasive approach.
Interventions
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PET imaging using [11C]DASB radioligand.
Subjects will be asked to complete a food choice task in PET/MRI. During the task, PET and MRI scans will be acquired simultaneously. This will allow us to see in real time during food choices the brain activations of the subjects. For imaging we will inject the DASB tracer intravenously. This radio ligand is a tracer that allows us to see the cerebral serotoninergic transmission by positron emission tomography.
Eye Tracker
The second technique used is the eye tracker that will allow us to analyze food avoidance behaviors through the eyes. With a "TOBII" eye tracker we wil be able to follow the gaze of the subjects during the food preference task. It is a non-invasive approach.
Eligibility Criteria
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Inclusion Criteria
* Subject affiliated or entitled to a social security scheme
* Anorexia nervosa common features : fear of weight gain, dysmorphophobia, BMI \< 17.5 kg/ m², amenorrhea
* Absence of food compulsions and purges
* Subgroup 1 (15 subjects) : STAI Y2 anxiety score \> 61
* Subgroup 2 (15 subjects) : STAI Y2 anxiety score \< 51
* BMI between 18.5 and 25 kg/ m²
* Absence of a psychological profile of eating disorder or other psychiatric disorders.
Exclusion Criteria
* Subject with heart failure
* Subject treated during the last three months with neuroleptics, and antiparkinsonian drugs, monoamine oxidase (MAO)-A or monoamine oxidase (MOA)-B inhibitors, tricyclic antidepressants, 5HT reuptake inhibitors, thymo regulators (lithium), antiepileptic dugs, codeine derivatives, morphinics, tramadol-containing products (Topalgic, …),dopaminergic drugs.
* Subjects with suspected pregnancy; Test β human chorionic gonadotropin (HCG) positive prior to examination.
* Subjects for whom MRI is contraindicated (pacemaker, intracerebral clips, prosthesis made of ferromagnetic material or claustrophobia).
* Subjects unable to sign written consent for participation in the study.
* Subject deprived of liberty by a judicial or administrative decision
16 Years
35 Years
FEMALE
Yes
Sponsors
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Centre Hospitalier Universitaire de Saint Etienne
OTHER
Responsible Party
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Principal Investigators
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Bogdan GALUSCA, PhD
Role: PRINCIPAL_INVESTIGATOR
Centre Hospitalier Universitaire de Saint Etienne
Locations
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CHU de Saint-Etienne
Saint-Etienne, , France
Countries
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Other Identifiers
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2021-000906-10
Identifier Type: EUDRACT_NUMBER
Identifier Source: secondary_id
20CH240
Identifier Type: -
Identifier Source: org_study_id
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