Interoception in Anorexia Nervosa

NCT ID: NCT04981626

Last Updated: 2022-07-26

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 50 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-02-14
• Study Completion Date: 2023-04-30

Brief Summary

Anorexia nervosa is a serious psychiatric illness whose causes remain poorly understood, and which remains difficult to treat to this day. Many clinical manifestations of this disease can have their origin in abnormalities in the perception of signals coming from inside the body, but this remains to be demonstrated. In recent years, research in healthy subjects has shown how the brain constantly perceives the viscera (heart, lungs, stomach). The examiners will use these new, objective and validated methods to explore how the brain processes information from the viscera (interoception) in anorexic patients. In practice, they will quantify the coupling between the cardiac cycle and involuntary eye movements, as well as between the respiratory cycle and voluntary actions such as pressing a button. Finally, by simultaneously recording the electrical activity of the brain, and that of the stomach, the examiners will measure the coupling between the brain and the stomach. All these measurements, which will be compared between a population of patients and healthy subjects, will make it possible to determine whether anorexic patients have an alteration in the perception of their internal body signals and whether this damage affects several organs.

Conditions

Anorexia; Anorexia Nervosa; Electrocardiogram; EEG

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Control

• Females
• Age : matched for the AN group
• No present or past eating disorders
• No past or current psychotic disorders
• No current substance abuse or dependence.
• No current psychiatric medication

Clinical and experimental session

Intervention Type: OTHER

Psychologic profile with standardized interview and scales (see below for details: SCID, BDI, STAI, BPQ, EDE Q, Pictorial Body Image Scale (PBIS) and EDI).

Measure the stomach-brain synchrony during EEG/EGG resting state, the distribution of voluntary actions across the respiratory phase, and the distribution of saccadic eye movements across the cardiac-cycle.

AN group

• Females
• 16 years ≤ Age ≤ 25 years
• Diagnostic of AN according to DSM-5 criteria
• No past or current psychotic disorders
• No current substance abuse or dependence (excluding tobacco).
• No current psychiatric medication

Clinical and experimental session

Intervention Type: OTHER

Psychologic profile with standardized interview and scales (see below for details: SCID, BDI, STAI, BPQ, EDE Q, Pictorial Body Image Scale (PBIS) and EDI).

Measure the stomach-brain synchrony during EEG/EGG resting state, the distribution of voluntary actions across the respiratory phase, and the distribution of saccadic eye movements across the cardiac-cycle.

Interventions

Clinical and experimental session

Psychologic profile with standardized interview and scales (see below for details: SCID, BDI, STAI, BPQ, EDE Q, Pictorial Body Image Scale (PBIS) and EDI).

Measure the stomach-brain synchrony during EEG/EGG resting state, the distribution of voluntary actions across the respiratory phase, and the distribution of saccadic eye movements across the cardiac-cycle.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Females
• 6 to 25 years old
• Diagnostic of AN according to DSM-5 criteria
• No past or current psychotic disorders
• No current substance abuse or dependence (excluding tobacco).
• No current psychiatric medication

• Females
• Age : matched for the AN group
• No present or past eating disorders
• No past or current psychotic disorders
• No current substance abuse or dependence.
• No current psychiatric medication

Exclusion Criteria

• age below 16 years and above 25 years,
• Past or current psychotic disorders,
• Current substance abuse or dependence (excluding tobacco)
• Opposition to participation has been expressed.

In addition, for the control group,

• Subjects with present or past eating disorders or current mental disorders will be excluded.

• Minimum Eligible Age: 16 Years
• Maximum Eligible Age: 25 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Laboratoire de Psychologie et NeuroCognition

OTHER

Sponsor Role: collaborator

University Hospital, Geneva

OTHER

Sponsor Role: collaborator

Fondation Santé des Étudiants de France

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Marco Solca, Dr

Role: PRINCIPAL_INVESTIGATOR

ENS

Locations

ENS

Paris, Île-de-France Region, France

Site Status: RECRUITING

Countries

France

Central Contacts

Nathalie Godart, PU-PH

Role: CONTACT

nathalie.godart@fsef.net

0145894339

Marco Solca, Dr

Role: CONTACT

marco.solca@hcuge.ch

Facility Contacts

Marco Solca, DR

Role: primary

Marco.solca@hcuge.ch

Other Identifiers

2021-A00811-40

Identifier Type: -

Identifier Source: org_study_id