Exploration of the Mechanisms of Vulnerability of Anorexia Nervosa at an Early Age : Study of the Cognitive Treatment of Food Stimuli and Body Image
NCT ID: NCT04037215
Last Updated: 2021-10-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
90 participants
INTERVENTIONAL
2019-11-19
2022-12-19
Brief Summary
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Detailed Description
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The objectives of this study are to:
Describe the cognitive treatment of early-onset AM patients with specific stimuli of the disorder (eating and body images) compared to age- and sex-matched control subjects:
* children controls not achieved with normal body mass index(BMI);
* children with unbalanced insulin-dependent type 1 diabetes, therefore subject to a strict diet that requires good nutritional knowledge and no weight judgment disorders.
Describe the links between cognitive treatment and clinical phenotype in patients with early onset AM, in particular severity of eating behaviour trouble symptomatology (TCA), psychiatric and somatic comorbidities, neuropsychological profile.
30 patients with early-onset AM. Two groups of control subjects (matched for age and gender): 30 subjects from the general population with a normal Body Mass Index (BMI) and 30 subjects with chronic somatic pathology (type 1 diabetes) without weight variation (good knowledge of dietary caloric values without impaired judgment about the caloric value of foods and representation of the body image of self and others) A total of 90 participantsPatients and controls without eating disorders will be recruited at Robert Debré Hospital, after signature of the authorization by the holder(s) of parental authority present at the time of hospitalization All patients treated in the department benefit from extensive phenotypic exploration, carried out in routine care.
For controls, phenotypic exploration will require a half-day evaluation.
Conditions
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Study Design
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NA
SINGLE_GROUP
For controls, phenotypic exploration will require a consultation with clinical examination including the search for psychiatric comorbidities and the completion of standardized questionnaires, exploration of the neuropsychological profile (with eye tracking, overall cognitive exploration, executive functions, social cognition and self-esteem).
Test results will not be returned except for screening requiring specific management. The information will then be returned to the child's parents by the investigating doctor, who will be responsible for organizing specific care whenever it is necessary.
OTHER
NONE
Study Groups
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COGNITIVE TREATMENT OF DIETARY STIMULI AND BODY IMAGE
In order to explore the cognitive treatment of patients with early onset anorexia nervosa in front of images of silhouettes and food, it is currently used in the child psychiatry department of the Robert Debré Hospital, the eye-tracking method. Eye tracking is a non-invasive and painless method of recording the path of vision on images presented on a computer screen. In order to understand the specificities of the eye path in sick patients, we will compare the data with those of controls without eating disorders.
STUDY OF THE COGNITIVE TREATMENT OF DIETARY STIMULI AND BODY IMAGE
Describe the cognitive treatment of patients with early onset anorexia nervosa in response to specific stimuli of the disorder (eating and body images), compared to age- and sex-matched control subjects:
* children controls not achieved with normal BMI;
* children with unbalanced insulin-dependent type 1 diabetes, therefore subject to a strict diet that requires good nutritional knowledge and no weight judgment disorders.
Interventions
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STUDY OF THE COGNITIVE TREATMENT OF DIETARY STIMULI AND BODY IMAGE
Describe the cognitive treatment of patients with early onset anorexia nervosa in response to specific stimuli of the disorder (eating and body images), compared to age- and sex-matched control subjects:
* children controls not achieved with normal BMI;
* children with unbalanced insulin-dependent type 1 diabetes, therefore subject to a strict diet that requires good nutritional knowledge and no weight judgment disorders.
Eligibility Criteria
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Inclusion Criteria
* Age 8 to 14 years,
* Early AM diagnosis (AM DSM-5 criteria, and presence of primary amenorrhea at diagnosis for girls),
* Follow-up in the Child Psychiatry Department of the Robert Debré Hospital,
* Affiliation to a social security system,
* Authorization of the holder(s) of parental authority and acceptance of the child to participate in this research.
Witnesses from the general population:
* Age 8 to 14 years,
* Normal Height-weight development defined by: Weight, Height, BMI between 10° and 90° percentile for age and sex, without changing the growth curve.
* Authorization of the holder(s) of parental authority and acceptance of the child to participate in this research
Witnesses with type 1 diabetes:
* Age 8 to 14 years,
* Type 1 diabetes for more than a year,
* Follow-up in the endocrinology department of the Robert Debré Hospital,
* Normal height-weight development defined by: Weight, Height, BMI between 10° and 90° percentile for age and sex, without changing the growth curve.
* No clear imbalance with HbA1c \<8.5%.
* Authorization of the holder(s) of parental authority and acceptance of the child to participate in this research
Exclusion Criteria
* Existence of an intellectual deficit (IQ \<70). The patient will not be able to have a new IQ test within one year of inclusion.
* Other Axis I disorder (Kiddie SAS)
* Existence of a severe neurosensory disorder
* Existence of a neurological disorder
* other eating disorders(DSM-5)
* Diabetes type 1
Witnesses :
* Any Axis I psychiatric disorder
* Existence of an intellectual deficit
* Existence of a severe neurosensory disorder
* Existence of a neurological disorder
* Long-term drug treatment (other than insulin for controls with type 1 diabetes)
* Type 1 diabetes (for controls in the general population)
Psychometric test taken in the year before inclusion
8 Years
14 Years
ALL
No
Sponsors
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Assistance Publique - Hôpitaux de Paris
OTHER
Responsible Party
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Principal Investigators
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Clarke Julia, PhD
Role: PRINCIPAL_INVESTIGATOR
APHP
Locations
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Hôpital Robert Debré
Paris, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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K170607J
Identifier Type: -
Identifier Source: org_study_id