Food Intake and IgA Microbiota in Anorexia Nervosa

NCT ID: NCT05842343

Last Updated: 2025-11-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

14 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-10-13

Study Completion Date

2024-02-02

Brief Summary

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Anorexia nervosa is characterized by intestinal dysbiosis, related to the feeding behavior impairment presented by these patients. Pathophysiologic hypotheses are involving the trouble of the microbiota-gut-brain axis in the field of mental diseases.

Detailed Description

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Anorexia nervosa is characterized by intestinal dysbiosis, related to the feeding behavior impairment presented by these patients. Here we aim to characterize the IgA-coated fraction of bacteria from the intestinal microbiota, linked to the regulation of the mucosal immune system and the epithelium physiology. Abnormalities of this microbiota are reported in inflammatory bowel disease and are associated to immune trouble. As food intake plays a key role in shaping microbiota, we aim to correlate data from IgA microbiota to food intake specificity, and to anorexia nervosa phenotypes.

Conditions

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Anorexia Nervosa Healthy Volunteer

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Acute anorexia nervosa

patient diagnose for a first episode of pure restrictive anorexia nervosa will be included. They will have stool sample and Food intake evaluation.

Group Type EXPERIMENTAL

Stool sample

Intervention Type OTHER

Purification by affinity of the IgA coated bacteria from a fecal solution. Genomic analysis of the bacteria for diversity and richness

Food intake evaluation

Intervention Type OTHER

Measure (by survey) of food group intake for : lipids /proteins / fibers / carbohydrates

Chronic anorexia nervosa

Patient diagnose for anorexia nervosa at least 5 years ago and still maintaining a significant thinness will be included. They will have stool sample and Food intake evaluation.

Group Type EXPERIMENTAL

Stool sample

Intervention Type OTHER

Purification by affinity of the IgA coated bacteria from a fecal solution. Genomic analysis of the bacteria for diversity and richness

Food intake evaluation

Intervention Type OTHER

Measure (by survey) of food group intake for : lipids /proteins / fibers / carbohydrates

Healthy control

Healthy Patient will be included. They will have stool sample and Food intake evaluation.

Group Type PLACEBO_COMPARATOR

Stool sample

Intervention Type OTHER

Purification by affinity of the IgA coated bacteria from a fecal solution. Genomic analysis of the bacteria for diversity and richness

Food intake evaluation

Intervention Type OTHER

Measure (by survey) of food group intake for : lipids /proteins / fibers / carbohydrates

Interventions

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Stool sample

Purification by affinity of the IgA coated bacteria from a fecal solution. Genomic analysis of the bacteria for diversity and richness

Intervention Type OTHER

Food intake evaluation

Measure (by survey) of food group intake for : lipids /proteins / fibers / carbohydrates

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* female subject, adult, affiliated to a social security system, under the care of the eating disorder department of university hospital of st Etienne
* presenting a diagnosis of pure restrictive anorexia nervosa.

For acute subgroup : BMI between 11 and 17.5 kg/m2, patient with a first episode of restrictive anorexia nervosa or with hyperphagic episodes.

For the chronic subgroup: BMI between 11 and 17.5 kg/m2, disease evolving for more than 5 years.

For Healthy volunteer: BMI between 20 and 24 kg/m², stable weight for the last 3 months, no eating disorder or history of eating disorder

Exclusion Criteria

* patient does not understand French.
* laxative treatment in progress or stopped for less than 15 days,
* antibiotic treatment in the two months preceding inclusion,
* pre-pro or symbiotic treatment in progress or in the month preceding inclusion,
* patient with one of the following comorbid disorders: celiac disease, chronic inflammatory bowel disease, lactose intolerance, unstabilized hyperthyroidism, unstabilized diabetes,
* subject under legal protective measures.
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Centre Hospitalier Universitaire de Saint Etienne

OTHER

Sponsor Role lead

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

OTHER

Sponsor Role collaborator

Laboratory Physiopathologie et biotherapies des infections muqueuses (GIMAP)

UNKNOWN

Sponsor Role collaborator

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Tristan GABRIEL-SEGARD, Md

Role: PRINCIPAL_INVESTIGATOR

CHU SAINT-ETIENNE

Locations

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Chu Saint-Etienne

Saint-Etienne, , France

Site Status

Countries

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France

Other Identifiers

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2023-A00318-37

Identifier Type: OTHER

Identifier Source: secondary_id

22CH356

Identifier Type: -

Identifier Source: org_study_id

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