Patient-derived Stem Cell Models of Anorexia Nervosa

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-08-25

Study Completion Date

2026-12-31

Brief Summary

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Experimental and genetic data, as well as brain imaging, support a role of the hypothalamic Arcuate nucleus neurons and their communication with surrounding microglia in anorectic conditions, but it has until recently not been possible to explore these cells at a molecular level in anorexia nervosa (AN) patients. This attributed to the obvious lack of valid tissue and non-invasive imaging techniques of high enough resolution. Stem cell models have evolved as a useful tool for the exploration of other neuropsychiatric disorders with a comparably high genetic contribution as AN. The investigators will here use patient-derived induced pluripotent stem cells (iPSCs) to profile Arc neurons and peripheral blood mononuclear cell (PBMC) derived microglia in AN, thus defining molecules to explore as drug targets.

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Detailed Description

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Conditions

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Anorexia Nervosa

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

OTHER

Study Groups

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anorexia nervosa

observational

Intervention Type OTHER

Profiling the function of iPSC derived Arcuate neurons and PBMC derived microglia

healthy controls

observational

Intervention Type OTHER

Profiling the function of iPSC derived Arcuate neurons and PBMC derived microglia

Interventions

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observational

Profiling the function of iPSC derived Arcuate neurons and PBMC derived microglia

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* female
* 18-45 years of age
* AN restrictive diagnosis as main diagnosis
* more than 5 years duration

* female
* 18-45 years of age
* BMI 18,5 - 25