Anorexia Nervosa and Brain in Adolescence

NCT ID: NCT06380257

Last Updated: 2024-04-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-09-30

Study Completion Date

2030-12-31

Brief Summary

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Aims of this follow-up study are to investigate effects of anorexia nervosa on brain structure and functions in adolescence.

Detailed Description

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Anorexia nervosa is severe mental health problem with increased incidence rates in adolescence. Etiology of anorexia nervosa is still mostly unkonwn. Adolescence is also critical period of brain development.

Aims of this follow-up study are to investigate effects of anorexia nervosa on brain structure and functions in both acute and remission state of anorexia nervosa in adolescence.

Study group are young anorexia nervosa patients, and control group are healthy same-aged students.

Research methods include non-invasive brain imaging methods such as Transcranial Magnetic Stimulation (TMS), and Magnetic Resonance Imaging (MRI). Other research methods are assessment of body composition, laboratory tests, self-rated questionnaires and psychiatric interview.

Conditions

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Anorexia Nervosa

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Study group

Adolescents diagnosed with anorexia nervosa or atypical anorexia nervosa.

Observational study methods

Intervention Type OTHER

Neuroimaging, body compostion, laboratory tests and psychiatric interview in study and in control groups.

Control Group

Healthy adolescents.

Observational study methods

Intervention Type OTHER

Neuroimaging, body compostion, laboratory tests and psychiatric interview in study and in control groups.

Interventions

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Observational study methods

Neuroimaging, body compostion, laboratory tests and psychiatric interview in study and in control groups.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Control group : 1) age 16-19 years, 2) BMI over 19.0, 3) No lifetime obesity (BMI over 30) nor eating disorder.

Exclusion Criteria

1\) glucose metabolism disorder or any chronic medical disorder, or medicine with possible effects on neurotransmitters, 2) previous mental health problem (excluded anorexia nervosa or atypical anorexia nervosa in study group), 3) smoking, nicotine products, alcohol or any other substance abuse or dependence, 4) contraindication for used brain imaging method.
Minimum Eligible Age

16 Years

Maximum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Kuopio University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Virve Kekkonen

Specialist in adolescent psychiatry, clinical lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Virve Kekkonen, M.D.

Role: PRINCIPAL_INVESTIGATOR

Kuopio University Hospital

Central Contacts

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Virve Kekkonen, M.D.

Role: CONTACT

+35817173311

Other Identifiers

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ANBA

Identifier Type: -

Identifier Source: org_study_id

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