Drugs Experience for Adolescents With Anorexia

NCT ID: NCT06211517

Last Updated: 2025-09-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-05-20

Study Completion Date

2027-12-31

Brief Summary

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The purpose of this study is to access to the experiences of adolescents, their parents and healthcare professionals regarding psychotropic drugs in anorexia nervosa.

No preconceived ideas (according to qualitative methods) but a question: what are the participants' perceptions and experiences of psychotropic drugs in anorexia nervosa? In an adolescent medicine department.

Detailed Description

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Psychotropic prescription is common to adolescents suffering from anorexia nervosa. A first qualitative study (E3A Protocol "Experience of adolescents with anorexia nervosa toward antidepressants") looked at the experience of antidepressants among 15 adolescents suffering from anorexia nervosa. Analysis of the interviews identified two meta-themes:

1. Reactions to the proposal of antidepressant with an opposition phase (about the existence of depressive symptoms and about negative preconceptions) and need to share with family and other teenagers.
2. Reactions to antidepressant use with ambivalence and an initial perception of coercion, and effects of antidepressants (psychological effects, effects on the body and on anorexia nervosa and effects perceived through the eyes of others).

Nine adolescents (out of 15) were also taking an atypical antipsychotic (APA) often prescribed in case of anorexia nervosa resistance.

The need to share with family about the proposal of antidepressant and the effects perceived through the eyes of others (including parent's eyes) lead us to take an interest in parents perceptions.

Two decisive periods were identified: What do healthcare professionals think about psychotropic treatments for anorexia nervosa in adolescence? How do they propose treatment?

Interviewing teenagers, their parents as well as healthcare professionals, will enable to access to the complexity of representations and experiences of these psychotropic drugs in anorexia nervosa.

Conditions

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Anorexia Nervosa Psychotropic Drugs Adolescent

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Adolescents

Adolescents suffering from anorexia nervosa 12 to 25 years

Semi-structured interviews with visual mediations

Intervention Type OTHER

Semi-structured interviews with visual mediations / An hour-long interview

Parents

Parents whose adolescents suffer from anorexia nervosa

Semi-structured interviews with visual mediations

Intervention Type OTHER

Semi-structured interviews with visual mediations / An hour-long interview

Healthcare professionals

Healthcare professionals in charge of adolescents suffering from anorexia nervosa

Semi-structured interviews

Intervention Type OTHER

Semi-structured interviews

Interventions

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Semi-structured interviews with visual mediations

Semi-structured interviews with visual mediations / An hour-long interview

Intervention Type OTHER

Semi-structured interviews

Semi-structured interviews

Intervention Type OTHER

Other Intervention Names

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Qualitative interviews Qualitative interviews

Eligibility Criteria

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Inclusion Criteria

Adolescents :

* Aged 12 to 25 years
* Suffering from anorexia nervosa (restrictive or mixed) according to DSM-5 (Diagnostic and Statistical Manual) criteria
* Received psychotropic drugs (antidepressant treatment and/or APA) during their care, either ongoing or discontinued before this study started


Healthcare Professionals working with adolescents suffering from eating disorders

Exclusion Criteria

Adolescents :

* Atypical eating disorder that does not meet the DSM-5 criteria for restrictive or mixed anorexia nervosa
* BMI\<15
* Prescription of an antidepressant other than an SSRI (Selective Serotonin Reuptake Inhibitor)
* Prescription of an APA for the indication of psychotic symptoms
Minimum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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URC-CIC Paris Descartes Necker Cochin

OTHER

Sponsor Role collaborator

Assistance Publique - Hôpitaux de Paris

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Corinne Blanchet, MD

Role: STUDY_DIRECTOR

Cochin Hospital (maison de Solenn)

Marie Rose Moro, MD, PhD

Role: STUDY_DIRECTOR

Cochin Hospital (maison de Solenn)

Maude Ludot-Gregoire, MD

Role: PRINCIPAL_INVESTIGATOR

Cochin Hospital (maison de Solenn)

Locations

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Maison de Solenn Maison des Adolescents, Cochin Hospital

Paris, IDF, France

Site Status RECRUITING

Countries

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France

Central Contacts

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Maude Ludot-Gregoire, MD, psychiatrist

Role: CONTACT

00 33 1 58 41 28 41

Marie Benhammani-Godard

Role: CONTACT

00 33 1 58 41 11 90

Facility Contacts

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Marie Rose Moro, MD, PhD

Role: primary

00 33 1 58 41 28 01

Sophie Wery

Role: backup

00 33 1 58 41 28 01

References

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Ludot-Gregoire M, David V, Carretier E, Lachal J, Moro MR, Blanchet C. Subjective Experience of Antidepressant Prescription Among Adolescents With Anorexia Nervosa. Front Psychiatry. 2022 Apr 4;13:770903. doi: 10.3389/fpsyt.2022.770903. eCollection 2022.

Reference Type BACKGROUND
PMID: 35444576 (View on PubMed)

Related Links

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https://doi.org/10.3389/fpsyt.2022.770903

First qualitative study (E3A Protocol)

Other Identifiers

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2022-A02141-42

Identifier Type: OTHER

Identifier Source: secondary_id

APHP230062

Identifier Type: -

Identifier Source: org_study_id

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