Food Intake and the Adolescent Brain

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

63 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-12-30

Study Completion Date

2024-09-30

Brief Summary

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The brain plays an integral role in how and what people eat. However, the brain's contribution to overeating is not well understood during sensitive developmental periods such as adolescence, when excessive weight gain and obesity prevalence are a significant concern.The proposed study will use functional magnetic resonance imaging to examine how the brain's response to excess energy is related to overeating in adolescents with and without obesity.

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Detailed Description

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Conditions

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Feeding Behavior Brain Adolescent

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Energy Neutral

Bottled water (300 ml) with added fruit punch-flavored non-nutritive sweetener (aspartame) will be used as the energy neutral stimulus.

Energy Stimulus

Intervention Type DIETARY_SUPPLEMENT

Energy stimulus (energy surplus v. energy neutral) will be randomly assigned at the first brain imaging visit. At the second brain imaging visit, the participant will receive the alternate stimulus from what they received at the first brain imaging visit.

Energy Surplus

300ml fruit punch-flavored Glucola (75-gram\[g\], Azer Scientific) will be used as the energy surplus stimulus.

Energy Stimulus

Intervention Type DIETARY_SUPPLEMENT

Energy stimulus (energy surplus v. energy neutral) will be randomly assigned at the first brain imaging visit. At the second brain imaging visit, the participant will receive the alternate stimulus from what they received at the first brain imaging visit.

Interventions

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Energy Stimulus

Energy stimulus (energy surplus v. energy neutral) will be randomly assigned at the first brain imaging visit. At the second brain imaging visit, the participant will receive the alternate stimulus from what they received at the first brain imaging visit.

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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aspartame Glucola glucose

Eligibility Criteria

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Inclusion Criteria

* male or female
* 13-18 years-old
* resident of Colorado

Exclusion Criteria

* weigh less than 88 pounds or have a BMI% rank of \<10% for age and sex;
* have a physician's diagnosis of metabolic syndrome or diabetes (Type 1 or 2);
* have a physician's diagnosis of anorexia nervosa or bulimia nervosa;
* currently taking anti-psychotic medications (not including anti-depressant or anti- anxiety medications);
* have a non-MRI safe device (e.g. pacemaker or defibrillator) or metal in the body (e.g. metal pins, shrapnel);
* experience symptoms of claustrophobia when in small or closed-off places;
* are pregnant or plan to become pregnant

Minimum Eligible Age

13 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes