Binges and Neural Variability

NCT ID: NCT04184856

Last Updated: 2021-08-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

61 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-12-06

Study Completion Date

2021-05-31

Brief Summary

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People who suffer from binge eating disorder experience recurrent episodes of binge eating.During these episodes, they consume an unusually large amount of food in a short amount of time and experience loss of control over eating. However, why such binge eating episodes occur is still largely unknown. This makes it difficult to develop targeted treatments. In this project, the experimenters are investigating the brain mechanisms that give rise to the disorder. They hypothesize that the binge eating episodes are due to an increased variability in reward processing, which they will assess repeatedly over days. They will test this hypothesis using mathematical models based on behavioural and MRI measurements that are related to the processing of rewards.

Detailed Description

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Conditions

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Binge-Eating Disorder

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Binge eating disorder (BED) patients

Individuals with BED diagnosis.

fMRI

Intervention Type DIAGNOSTIC_TEST

(Imaging while) performing reward related tasks.

non-BED controls

Individuals that do not experience binges

fMRI

Intervention Type DIAGNOSTIC_TEST

(Imaging while) performing reward related tasks.

subsyndromal BED controls

individuals that experience binges but do not fulfill the requirements for BED diagnosis.

fMRI

Intervention Type DIAGNOSTIC_TEST

(Imaging while) performing reward related tasks.

Interventions

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fMRI

(Imaging while) performing reward related tasks.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Binge eating disorder diagnosis
* Subsyndromal binge eating (control)

Exclusion Criteria

* high risk of suicide
* co-occurring psychotic, bi-polar disorders, alcohol/substance dependence within the past six months
* lack of capacity for consent
* medical disorders that would affect weight and ability to participate
* insufficient German language skills (assessment will be in German)
* taking medication that would affect weight
* irremovable metal attached to the body (e.g. piercings)
* irremovable medical devices (e.g. pacemakers)
* any trauma or surgery which may have left ferromagnetic material in the body
* large tattoos
* pregnancy
* claustrophobia
Minimum Eligible Age

18 Years

Maximum Eligible Age

69 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Else Kröner Fresenius Foundation

OTHER

Sponsor Role collaborator

University Hospital Tuebingen

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Nils B Kroemer, Dr

Role: PRINCIPAL_INVESTIGATOR

University Hospital Tuebingen

Locations

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Psychological Institute, University of Tübingen

Tübingen, Deutschland (deu), Germany

Site Status

Countries

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Germany

Other Identifiers

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BEDVAR

Identifier Type: -

Identifier Source: org_study_id

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