Study of Emotional Regulation and Underlying Prefrontal Activity in Binge Eating Disorder
NCT ID: NCT06864065
Last Updated: 2025-07-22
Study Results
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Basic Information
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RECRUITING
NA
80 participants
INTERVENTIONAL
2025-06-24
2026-10-30
Brief Summary
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The aim of this study is to compare the prefrontal processing of cognitive control of emotions between BED and EE and to compare the emotional processing and emotional experience between BED and EE.
The study will thus compare four experimental groups: patients with BED, BMI-matched healthy volunteers with EE, BMI-matched healthy volunteers, and healthy volunteers of normal weight without BED.
Participants will perform a down-regulation task of negative emotions elicited by negative pictures. During this task, their cerebral activity will be recorded using functional near-infrared spectroscopy (fNIRS), as well as their autonomous activity (skin conductance, pulse rate, respiration rate).
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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Patients with binge eating desorders
Patients with binge eating desorders
Emotion regulation task (fNIRS recording during the emotional regulation task)
No drugs were used in this study. All participants perform an emotion regulation task. More precisely, they have to down regulate negative emotions elicited by negative pictures using a cognitive reaprasal strategy. To this end, they have to change the meaning of the picture they are watching in order to decrease motional intensity.
healthy volunteers with a low score at the emotion eating scale compare to median
group matched with patients for age and body mass index
Emotion regulation task (fNIRS recording during the emotional regulation task)
No drugs were used in this study. All participants perform an emotion regulation task. More precisely, they have to down regulate negative emotions elicited by negative pictures using a cognitive reaprasal strategy. To this end, they have to change the meaning of the picture they are watching in order to decrease motional intensity.
healthy volunteers with a high score at the emotion eating scale compare to median
group matched with patients for age and body mass index
Emotion regulation task (fNIRS recording during the emotional regulation task)
No drugs were used in this study. All participants perform an emotion regulation task. More precisely, they have to down regulate negative emotions elicited by negative pictures using a cognitive reaprasal strategy. To this end, they have to change the meaning of the picture they are watching in order to decrease motional intensity.
healthy volunteers normo-weight group with a low score at the emotion eating scale compare to median
healthy volunteers with normo-weight group matched with patients only in age but not in Body Mass Iindex with an Emotional Eating score below the median
Emotion regulation task (fNIRS recording during the emotional regulation task)
No drugs were used in this study. All participants perform an emotion regulation task. More precisely, they have to down regulate negative emotions elicited by negative pictures using a cognitive reaprasal strategy. To this end, they have to change the meaning of the picture they are watching in order to decrease motional intensity.
Interventions
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Emotion regulation task (fNIRS recording during the emotional regulation task)
No drugs were used in this study. All participants perform an emotion regulation task. More precisely, they have to down regulate negative emotions elicited by negative pictures using a cognitive reaprasal strategy. To this end, they have to change the meaning of the picture they are watching in order to decrease motional intensity.
Eligibility Criteria
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Inclusion Criteria
* Right-handed.
* For patients only : diagnosed with Binge Eating Desordors according to DSM criteria.
* Membership of a French social security scheme or beneficiary of such a scheme.
* Non-opposition of the subject to participate in the study.
Healthy volunteers only :
* Suffering from an eating disorder or any other psychiatric disorder.
* History of bariatric surgery.
All subjects (healthy volunteers and patients) :
* Rare obesity (genetic or syndromic).
* Specific addictions (substances or behaviors).
* Neurological disorders and/or history of stroke or head trauma.
* Presence of lesions, wounds or dermatitis at the sites where the recording devices are applied.
* Any serious acute or chronic illness other than the pathology under study, or any treatment likely to interfere with the evaluation of the parameter under study.
* Inability to follow protocol requirements.
* Subject unlikely to cooperate with the study and/or poor cooperation anticipated by the investigator.
* Subject unable to speak French and/or unable to read.
* Pregnant or breast-feeding women.
* Persons deprived of their liberty by judicial or administrative decision; persons under compulsory psychiatric care; persons admitted to a health or social institution for purposes other than research.
18 Years
60 Years
FEMALE
Yes
Sponsors
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INSERM UMR 1322 LINC
UNKNOWN
Centre Hospitalier Universitaire de Besancon
OTHER
Responsible Party
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Principal Investigators
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AMSALLEM Anne-Cécile, MD
Role: STUDY_DIRECTOR
CHU de Besançon
Locations
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UFC - UFR Santé
Besançon, , France
CHU de Besançon
Besançon, , France
CHU de Dijon
Dijon, , France
Countries
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Central Contacts
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Facility Contacts
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References
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Parker MN, Burton Murray H, Piers AD, Muratore A, Lowe MR, Manasse SM, Ayaz H, Juarascio AS. Prefrontal cortex activation by binge-eating status in individuals with obesity while attempting to reappraise responses to food using functional near infrared spectroscopy. Eat Weight Disord. 2023 Mar 30;28(1):34. doi: 10.1007/s40519-023-01558-z.
Dingemans A, Danner U, Parks M. Emotion Regulation in Binge Eating Disorder: A Review. Nutrients. 2017 Nov 22;9(11):1274. doi: 10.3390/nu9111274.
Arexis M, Feron G, Brindisi MC, Billot PE, Chambaron S. A scoping review of emotion regulation and inhibition in emotional eating and binge-eating disorder: what about a continuum? J Eat Disord. 2023 Nov 10;11(1):197. doi: 10.1186/s40337-023-00916-7.
Other Identifiers
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2024/886
Identifier Type: -
Identifier Source: org_study_id
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