Emotion Regulation and Binge Eating in Youth With Obesity

NCT ID: NCT02783872

Last Updated: 2021-02-23

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 59 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2016-11-30
• Study Completion Date: 2020-05-31

Brief Summary

This study will investigate neural activation patterns in emotion- and cognition-related brain regions during an emotion regulation task involving cognitive reappraisal, and their associations with age and pubertal status, among overweight children and adolescents with loss of control eating as compared to overweight and normal-weight controls.

Detailed Description

Loss of control (LOC) while eating (i.e., the sense that one cannot control what or how much one is eating) is prevalent among children and adolescents. LOC eating is associated with a range of physical and psychosocial health impairments, including obesity and the development of partial- and full-syndrome eating disorders. Early identification is thus critical for preventing or minimizing these adverse health outcomes. However, little is known about the development of LOC eating in children and, consequently, there is a paucity of effective interventions. Impairments in emotion regulation appear to be involved in the onset and maintenance of eating pathology in obese samples. To date, emotion regulation in youth with LOC eating problems is poorly understood, and research on underlying neurodevelopmental substrates is virtually nonexistent. The proposed research aims to characterize neurocircuitry involved in emotion regulation among 30 overweight children with LOC eating as compared to 30 overweight and 15 normal-weight controls without LOC. Participants will complete a cognitive reappraisal task whilst situated in an MRI scanner, the purpose of which is to characterize neural activity involved in reappraisal versus an emotion maintenance control condition. The proposed research aims to advance the field's understanding of the nature and correlates of LOC eating in overweight children so as to inform intervention development.

Conditions

Obesity; Binge-Eating Disorder

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Loss of control

30 overweight or obese (BMI≥85th %ile) youth endorsing loss of control eating within the past 3 months

No interventions assigned to this group

Overweight control

30 overweight or obese controls without any history of loss of control eating

No interventions assigned to this group

Normal-weight control

15 normal-weight controls without any history of loss of control eating

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Right-handed, aged 10-17 years.

Exclusion Criteria

Participants will be excluded if they

• are currently taking any medications known to affect mood or weight (e.g., antidepressants, steroids);
• have a current diagnosis of a mood disorder or an eating disorder involving purging or suppressed body weight (e.g., bulimia nervosa or anorexia nervosa);
• are unable to read and understand English fluently;
• are currently pregnant;
• are a current smoker; or
• have metallic foreign bodies, face or neck tattoos, or other conditions that would prohibit fMRI scanning. Participants will complete a mock scan (see below) to ensure that their head and trunk size can be comfortably accommodated in the scanner.

• Minimum Eligible Age: 10 Years
• Maximum Eligible Age: 17 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

The Miriam Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Andrea B Goldschmidt, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

The Miriam Hospital

Locations

The Miriam Hospital

Providence, Rhode Island, United States

Countries

United States

Other Identifiers

Miriam H

Identifier Type: -

Identifier Source: org_study_id