Biological Risk Factors for Onset of Binge Eating and Compensatory Behaviors

NCT ID: NCT03687346

Last Updated: 2021-11-03

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 88 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-08-03
• Study Completion Date: 2021-10-01

Brief Summary

The purpose of this proposed project is to test whether several biological factors (such as elevated brain reward region and attention region response to high-calorie foods, weaker inhibitory region response to high-calorie foods, habitual caloric deprivation, and elevated limbic region responsivity) increase the risk of problematic eating (bingeing and purging) in female adolescents.

Detailed Description

Participants will be adolescent girls aged 13-16, some of whom will have parental history of eating pathology. Participants will be recruited from the general population but their age, gender, and the presence of parental lifetime eating pathology will create a high-risk sample. The goals of the proposed project are to (1) conduct a prospective high-risk study to test whether proposed biological risk factors predict the future onset of core ED symptoms (e.g., binge eating, compensatory behaviors); (2) test hypotheses regarding how these biological risk factors and established self-report ED risk factors may work together to predict ED behavior onset; (3) examine if certain biological factors account for the effects of certain established self-reported ED risk factors (e.g., elevated brain response to thin models accounts for the effect of questionnaire-measured thin-ideal internalization). The participants will complete a baseline assessment and then follow-ups assessments over a span of three years. In addition, participants will complete one fMRI scan after the first assessment.

During the COVID-19 shelter-at-home order, the investigators will not measure in person only outcomes including fMRI scans, height and weight measurement for BMI calculation nor IAT computer paradigms for all participants that have assessments due during this order.

Conditions

Eating Disorder

Keywords

fMRI; Eating disorder; adolescent

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

High Risk Group

Parental history of eating pathology

No interventions assigned to this group

Low Risk Group

No parental history of eating pathology

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Female
• Aged 13-16 years

Exclusion Criteria

• Adolescents who report functional magnetic resonance imaging (fMRI) contraindications
• Current Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5) substance abuse disorder, eating disorder (ED), conduct disorder, attention deficit hyperactivity disorder (ADHD), or bipolar disorder
• Weekly or greater use of psychoactive drugs (e.g., analgesics, cocaine, marijuana)
• Serious medical complications (e.g., cancer, diabetes)
• History of head injury
• Relevant food allergies
• BMI > 35

• Minimum Eligible Age: 13 Years
• Maximum Eligible Age: 16 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Oregon Research Institute

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Eric Stice, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Stanford University

Locations

Oregon Research Institute

Eugene, Oregon, United States

Countries

United States

References

Stice E, Yokum S, Rohde P, Cloud K, Desjardins CD. Comparing healthy adolescent females with and without parental history of eating pathology on neural responsivity to food and thin models and other potential risk factors. J Abnorm Psychol. 2021 Aug;130(6):608-619. doi: 10.1037/abn0000686.

Reference Type: DERIVED

PMID: 34553956 (View on PubMed)

Other Identifiers

BioRF Pilot

Identifier Type: -

Identifier Source: org_study_id