Investigating the Acute Effects of Flavonoids in Blueberries on Cognitive Function.
NCT ID: NCT01289860
Last Updated: 2013-02-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
47 participants
INTERVENTIONAL
2009-05-31
2013-01-31
Brief Summary
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It was predicted that the flavonoids in the blueberry drink would lead to improved performance on the cognitive tests and vascular reactivity measure compared to following the control drink. It was thought this could be due to increased vaso-dilation and improving blood flow to the brain which was investigated in an extension to the project where a sample of individuals underwent brain imaging in an MRI scanner pre and post a blueberry and a control drink.
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Detailed Description
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Blood and urine samples will be analysed for flavonoid levels and Brain Derived Neurotrophic Factor, a biomarker of memory and learning, flavonoids may lead to increased BDNF production through the ERK-CREB-BDNF pathway.
Flavonoids may also increase nitric oxide production and improve the flexibility of the blood vessels hence the measure of vascular reactivity using the Digital Volume Pulse machine. This can lead to increased vaso-dilation and blood flow to the brain, therefore an fMRI study was carried out the investigate this using arterial spin labeling following acute blueberry supplementation compared to a control drink.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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Blueberry drink
30g of blueberry powder (equivalent to 200g fresh blueberries) and 300ml of semi-skimmed milk
Flavonoids
475g of anthocyanidins in 300ml of blueberry drink.
Control drink
29g of powder consisting of sugars and vitamin C, values of which were matched to that of the blueberry drink, with 1 g of citric acid to match for taste.
Control
29g powder: sugars (glucose, sucrose, fructose), vitamin C and citric acid.
Interventions
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Flavonoids
475g of anthocyanidins in 300ml of blueberry drink.
Control
29g powder: sugars (glucose, sucrose, fructose), vitamin C and citric acid.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Not taking any medication or supplements (or willing to stop taking supplements for duration of study)
* Not lactose intolerant
* Willing to give blood and urine samples
* Not partaking in frequent vigorous exercise
* Not suffering from or history of depression
Exclusion Criteria
* BMI \> 30
* Cholesterol \> 6
* Diabetes or other serious medical condition
* Lactose intolerant
* Any learning difficulty e.g. dyslexia
18 Years
75 Years
ALL
Yes
Sponsors
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University of Reading
OTHER
Responsible Party
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Jeremy Paul Edward Spencer
Professor of Nutritional Medicine
Principal Investigators
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Jeremy PE Spencer, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Reading
Laurie T Butler, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Reading
Locations
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University of Reading
Reading, Berkshire, United Kingdom
Countries
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Other Identifiers
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UReading_2010_01
Identifier Type: -
Identifier Source: org_study_id
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