The Effects of a Single Dose of Wild Blueberries on Mood and Cognition in Healthy Young Adults

NCT ID: NCT04935099

Last Updated: 2021-09-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

33 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-05-26

Study Completion Date

2021-08-27

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study aims to investigate whether consuming a drink containing powdered blueberries (equivalent to 150 g fresh fruit) can improve mood and cognition in healthy young adults. Blood biomarkers of inflammation and neurotransmitter turnover will be analyzed as well as responses to computer-based cognitive tasks designed to measure verbal memory, executive function, and emotional processing.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The present study will examine the psychological effects of a single dose of freeze-dried wild blueberries using a randomized, double-blind, placebo-controlled, counterbalanced, crossover design. A total of 30 healthy young adults will consume two drinks: one containing 22 g blueberry powder and the other containing 22 g matched placebo powder in counterbalanced order one week apart. The investigators will assess changes in transient mood, cognitive-emotional function, and serum biomarkers of inflammation, neuroplasticity, and monoamine metabolism from baseline to 2 hours post-ingestion.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Mood Affect Cognition

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Blueberry/Placebo

In this arm, participants will receive the blueberry intervention first, followed by the placebo one week later.

Group Type EXPERIMENTAL

Wild blueberry powder

Intervention Type DIETARY_SUPPLEMENT

22 g freeze-dried wild blueberry (Vaccinium angustifolium) powder, mixed with 250 ml water, and served in an opaque container.

Placebo powder

Intervention Type DIETARY_SUPPLEMENT

22 g placebo powder matched for macronutrients and flavor, mixed with 250 ml water, and served in an opaque container.

Placebo/Blueberry

In this arm, participants will receive the placebo first, followed by the blueberry intervention one week later.

Group Type EXPERIMENTAL

Wild blueberry powder

Intervention Type DIETARY_SUPPLEMENT

22 g freeze-dried wild blueberry (Vaccinium angustifolium) powder, mixed with 250 ml water, and served in an opaque container.

Placebo powder

Intervention Type DIETARY_SUPPLEMENT

22 g placebo powder matched for macronutrients and flavor, mixed with 250 ml water, and served in an opaque container.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Wild blueberry powder

22 g freeze-dried wild blueberry (Vaccinium angustifolium) powder, mixed with 250 ml water, and served in an opaque container.

Intervention Type DIETARY_SUPPLEMENT

Placebo powder

22 g placebo powder matched for macronutrients and flavor, mixed with 250 ml water, and served in an opaque container.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* 18 to 25 years of age
* Willingness to provide blood samples

Exclusion Criteria

* Allergy to blueberries or any other Vaccinium species
* Diagnosis or symptoms of anxiety, depression, or other mental health conditions
* Any medically significant condition (e.g. anemia, gastrointestinal disorders, diabetes)
* Use of psychoactive medication or recreational drugs in the last two weeks
* Current use of medication that could interact with the intervention (e.g. antibiotics)
* Obesity or underweight
* Participation in other interventional studies in the last month
* Pregnancy or lactation
Minimum Eligible Age

18 Years

Maximum Eligible Age

25 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Wild Blueberry Association of North America

OTHER

Sponsor Role collaborator

University of Reading

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Prof Claire Williams

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

School of Psychology and Clinical Languages, University of Reading

Reading, Berkshire, United Kingdom

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United Kingdom

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

21/09

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

The Blueberry Study
NCT04421950 COMPLETED NA